Prenatal exposure to a mixture of organochlorines and metals and internalizing symptoms in childhood and adolescence

Details

• Alternative Title:
  Environ Res
• Personal Author:
  Rokoff, Lisa B. ; Shoaff, Jessica R. ; Coull, Brent A. ; Enlow, Michelle Bosquet ; Bellinger, David C. ; Korrick, Susan A.
• Description:
  Background:
  
  Although prenatal chemical exposures influence neurobehavior, joint exposures are not well explored as risk factors for internalizing disorders through adolescence.
  
  Objective:
  
  To evaluate associations of prenatal organochlorine and metal exposures, considered individually and as a mixture, with mid-childhood and adolescent internalizing symptoms.
  
  Methods:
  
  Participants were 468 children from a prospective cohort recruited at birth (1993-1998) in New Bedford, Massachusetts. Organochlorines (hexachlorobenzene, p,p'-dichlorodiphenyl dichloroethylene, polychlorinated biphenyls) and metals (lead, manganese) were analyzed in cord blood. Internalizing symptoms (anxiety, depressive, somatic) were assessed via multiple informants on the Conners’ Rating Scale (CRS) at 8-years and Behavior Assessment System for Children, Second Edition (BASC-2) at 15-years; higher T-scores indicate greater symptoms. Overall and sex-specific covariate-adjusted associations were evaluated using Bayesian Kernel Machine Regression (BKMR) and five-chemical linear regression models.
  
  Results:
  
  The cohort was socioeconomically diverse (35% household income <$20,000; 55% maternal ≤high school education at birth). Most chemical concentrations were consistent with background levels [e.g., median(range) cord blood lead: 1.1(0-9.4) μg/dL]. BKMR suggested linear associations and no interactions between chemicals. The overall mixture was positively associated with Conners’ Parent Rating Scale (CPRS) and BASC-2 Self Report of Personality (SRP) anxiety and depressive symptoms, and negatively with somatic symptoms. Prenatal lead was positively associated with adolescent anxiety symptoms [1.56 (95% CI: 0.50,2.61) BASC-2 SRP Anxiety score increase per doubling lead]. For CRPS and BASC-2 SRP, a doubling of cord blood manganese was positively associated with internalizing symptoms for girls [e.g., 3.26 (95% CI: 0.27,6.25) BASC-2 SRP Depression score increase], but not boys. Organochlorine exposures were not adversely associated with internalizing symptoms.
  
  Discussion:
  
  Low-level prenatal lead exposure was positively associated with adolescent anxiety symptoms, and prenatal manganese exposure was positively associated with internalizing symptoms for girls from mid-childhood through adolescence. In utero neurotoxicant metal exposures may contribute to the emergence of anxiety and depression.
  
  
• Subjects:
  Adolescent Bayes Theorem Child Female Humans Hydrocarbons, Chlorinated Infant, Newborn Male Polychlorinated Biphenyls Pregnancy Prenatal Exposure Delayed Effects Prospective Studies

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• Keywords:
  Chemical Mixtures Children’s Health Internalizing Symptoms Metals Organochlorines Prenatal Exposure
• Source:
  Environ Res. 208:112701
• Pubmed ID:
  35016863
• Pubmed Central ID:
  PMC8917058
• Document Type:
  Journal Article
• Funding:
  P30 ES000002/ES/NIEHS NIH HHSUnited States/ ; P42 ES005947/ES/NIEHS NIH HHSUnited States/ ; R01 ES014864/ES/NIEHS NIH HHSUnited States/ ; T42 OH008416/OH/NIOSH CDC HHSUnited States/
• Volume:
  208
• NIOSHTIC Number:
  nn:20065510
• Collection(s):
  CDC Public Access National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5888ecd6834c596e2242b38217e179e9a49bb77f998f7c6a7f6b403b7fb23e359d83595a1dde9656f57c61ad453ba749f255e819deca267dc6cd89fcb7449da5
• Download URL:
  https://stacks.cdc.gov/view/cdc/115444/cdc_115444_DS1.pdf
• File Type:
  [PDF - 1.29 MB ]