Effectiveness of Maternal Vaccination with mRNA COVID-19 Vaccine During Pregnancy Against COVID-19–Associated Hospitalization in Infants Aged <6 Months — 17 States, July 2021–January 2022

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Halasa, Natasha B. ; Olson, Samantha M. ; Staat, Mary A. ; Newhams, Margaret M. ; Price, Ashley M. ; Boom, Julie A. ; Sahni, Leila C. ; Cameron, Melissa A. ; Pannaraj, Pia S. ; Bline, Katherine E. ; Bhumbra, Samina S. ; Bradford, Tamara T. ; Chiotos, Kathleen ; Coates, Bria M. ; Cullimore, Melissa L. ; Cvijanovich, Natalie Z. ; Flori, Heidi R. ; Gertz, Shira J. ; Heidemann, Sabrina M. ; Hobbs, Charlotte V. ; Hume, Janet R. ; Irby, Katherine ; Kamidani, Satoshi ; Kong, Michele ; Levy, Emily R. ; Mack, Elizabeth H. ; Maddux, Aline B. ; Michelson, Kelly N. ; Nofziger, Ryan A. ; Schuster, Jennifer E. ; Schwartz, Stephanie P. ; Smallcomb, Laura ; Tarquinio, Keiko M. ; Walker, Tracie C. ; Zinter, Matt S. ; Gilboa, Suzanne M. ; Polen, Kara N. ; Campbell, Angela P. ; Randolph, Adrienne G. ; Patel, Manish M. ; Zambrano, Laura D. ; Murdock, Meghan ; Gaspers, Mary Glas ; Kelley, Connor P. ; Typpo, Katri V. ; Mourani, Peter M. ; Sanders, Ronald C. ; Smith, Chelsea ; Yates, Masson ; Crane, Katheryn ; Lionetti, Geraldina ; Murcia-Montoya, Juliana ; Villarreal-Chico, Denise ; Hakimi, Daniel ; Skura, Adam L. ; Carson, Imogene ; Lockwood, Justin M. ; Port, Emily ; Chatani, Brandon M. ; Baida, Nadine ; Hussaini, Laila ; Khan, Hassan A. ; Rhodes, Simone T. ; Rowan, Courtney M. ; Stumpf, Mary ; Johnston, Marla S. ; Berbert, Laura ; Boutselis, Benjamin J. ; Chen, Sabrina R. ; He, Jie ; Kucukak, Suden ; McCadden, Timothy P. ; Orzel, Amber O. ; Weller, Edie ; Moran, Patrick ; Bruno, Ellen R. ; Goertzen, Lexie A. ; Behl, Supriya ; Drapeau, Noelle M. ; Malloch, Lacy ; Martin, Lora ; Palmer, April ; Santos, Roberto P. ; Kietzman, Abigail ; Sullivan, Melissa ; Hoody, Lauren A. ; Rinehart, Valerie H. ; Bennett, Paris C. ; Tomcany, Merry L. ; Twinem, Nicole A. ; Rohlfs, Chelsea C. ; Wolfe, Amber ; Douglas, Rebecca L. ; Phengchomphet, Kathlyn ; Bickford, Megan M. ; Wakefield, Lauren E. ; Golchha, Meena ; Stewart, Laura S. ; Oates, Jennifer N. ; Bowens, Cindy ; Maamari, Mia
• Corporate Authors:
  Overcoming COVID-19 Investigators ; Overcoming COVID-19 Network
• Description:
  COVID-19 vaccination is recommended for persons who are pregnant, breastfeeding, trying to get pregnant now, or who might become pregnant in the future, to protect them from COVID-19.| Infants are at risk for life-threatening Complications from COVID-19, including acute respiratory failure (1). Evidence from other vaccine-preventable Diseases suggests that maternal immunization can provide protection to infants, especially during the high-risk first 6 months of life, through passive transplacental antibody transfer (2). Recent studies of COVID-19 vaccination during pregnancy suggest the possibility of transplacental transfer of SARS-CoV-2-specific antibodies that might provide protection to infants (3-5); however, no epidemiologic evidence currently exists for the protective benefits of maternal immunization during pregnancy against COVID-19 in infants. The Overcoming COVID-19 network conducted a test-negative, case-control study at 20 pediatric hospitals in 17 states during July 1, 2021-January 17, 2022, to assess effectiveness of maternal completion of a 2-dose primary mRNA COVID-19 vaccination series during pregnancy against COVID-19 hospitalization in infants. Among 379 hospitalized infants aged <6 months (176 with COVID-19 [case-infants] and 203 without COVID-19 [control-infants]), the median age was 2 months, 21% had at least one underlying medical condition, and 22% of case- and control-infants were born premature (<37 weeks gestation). Effectiveness of maternal vaccination during pregnancy against COVID-19 hospitalization in infants aged <6 months was 61% (95% CI = 31%-78%). Completion of a 2-dose mRNA COVID-19 vaccination series during pregnancy might help prevent COVID-19 hospitalization among infants aged <6 months.
• Subjects:
  Case-Control Studies COVID-19 COVID-19 Vaccines Female Hospitalization Hospitals, Pediatric Humans Immunity, Maternally-Acquired Immunization, Passive Infant Infant, Newborn MRNA Vaccines Pregnancy SARS-CoV-2 Vaccines, Synthetic

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• Source:
  MMWR Morbidity Mortal Weekly Rep. 71(7):264-270
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/MMWRmm7107e3
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  35176002
• Pubmed Central ID:
  PMC8853480
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  7 pdf pages
• Volume:
  71
• Issue:
  7
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:2c9e2164ce7acff950f3fe9a37adb56e52232f981c5cbe60e286917f7076686aff9c1fb4d6dae008fff69cc1da6ae053fb66992c7e29de81b4f720ea36dab37d
• Download URL:
  https://stacks.cdc.gov/view/cdc/115072/cdc_115072_DS1.pdf
• File Type:
  [PDF - 458.20 KB ]