Association of schistosomiasis and HIV infections: A systematic review and meta-analysis

Details

• Alternative Title:
  Int J Infect Dis
• Personal Author:
  Patel, Pragna ; Rose, Charles E. ; Kjetland, Eyrun F. ; Downs, Jennifer A. ; Mbabazi, Pamela Sabina ; Sabin, Keith ; Chege, Wairimu ; Watts, D. Heather ; Secor, W. Evan
• Description:
  Background:
  
  Female genital schistosomiasis (FGS) affects up to 56 million women in sub-Saharan Africa and may increase risk of HIV infection.
  
  Methods:
  
  To assess the association of schistosomiasis with HIV infection, peer-reviewed literature published until 31 December 2018 was examined and a pooled estimate for the odds ratio was generated using Bayesian random effects models.
  
  Results:
  
  Of the 364 abstracts that were identified, 26 were included in the summary. Eight reported odds ratios of the association between schistosomiasis and HIV; one reported a transmission hazard ratio of 1.8 (95% CI, 1.2–2.6) among women and 1.4 (95% CI, 1.0–1.9) among men; 11 described the prevalence of schistosomiasis among HIV-positive people (range, 1.5–36.6%); and six reported the prevalence of HIV among people with schistosomiasis (range, 5.8–57.3%). Six studies were selected for quantitative analysis. The pooled estimate for the odds ratio of HIV among people with schistosomiasis was 2.3 (95% CI, 1.2–4.3).
  
  Conclusions:
  
  A significant association of schistosomiasis with HIV was found. However, a specific summary estimate for FGS could not be generated. A research agenda was provided to determine the effect of FGS on HIV infection. The WHO’s policy on mass drug administration for schistosomiasis may prevent HIV.
  
  
• Subjects:
  Bayes Theorem Female HIV Infections Humans Male Mass Drug Administration Prevalence
• Source:
  Int J Infect Dis. 102:544-553
• Pubmed ID:
  33157296
• Pubmed Central ID:
  PMC8883428
• Document Type:
  Journal Article
• Funding:
  001/WHO_/World Health OrganizationInternational/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/
• Place as Subject:
  Africa South of the Sahara
• Volume:
  102
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b5528257afabe788d797d8c4924a328350d9ca9ccf1566e9600fefa8dc906996
• Download URL:
  https://stacks.cdc.gov/view/cdc/114973/cdc_114973_DS1.pdf
• File Type:
  [PDF - 444.58 KB ]