i
Mycobacterium Tuberculosis Complex Drug Susceptibility Testing Program : Model performance evaluation program report of results March 2021
-
March 2021
-
[PDF-944.46 KB]
Details:
-
Alternative Title:CDC MPEP MTBC DST Report for March 2021 Survey
-
Personal Author:
-
Corporate Authors:
-
Description:The purpose of this report is to present results of the U.S. Centers for Disease Control and Prevention (CDC) Model Performance Evaluation Program (MPEP) for Mycobacterium tuberculosis complex (MTBC) drug susceptibility testing survey sent to participants in March 2021.
The Model Performance Evaluation Program (MPEP) is an educational self-assessment tool in which five isolates of M. tuberculosis complex (MTBC) are sent to participating laboratories biannually for staff to monitor their ability to determine drug resistance among the isolates. It is not a formal, graded proficiency testing program. The associated report includes results for a subset of laboratories performing drug susceptibility tests (DST) for MTBC in the United States. MPEP is a voluntary program, and this report reflects data received from participating laboratory personnel. This aggregate report is prepared in a format that will allow laboratory personnel to compare their DST results with those obtained by other participants using the same methods and drugs, for each isolate. We encourage circulation of this report to personnel who are either involved with DST or reporting and interpreting results for MTBC isolates.
CDC is neither recommending nor endorsing testing practices reported by participants. For standards, participants should refer to consensus documents published by the Clinical and Laboratory Standards Institute (CLSI), “M24: Susceptibility Testing of Mycobacteria, Nocardiae spp., and Other Aerobic Actinomycetes” [1]. Recently, World Health Organization (WHO) published two technical reports investigating critical concentrations, by method, for INH, RMP, EMB, PZA and twelve second-line antituberculosis drugs [2, 3]. Based on the systematic review data, recommendations were made for adjustments to critical concentrations for RMP, MOX, LEV, AMK and KAN for some methods
Running title: CDC MPEP MTBC DST Report for March 2021 Survey
CS 327352-A
MPEP-March-2021-Final-Report.pdf
-
Subjects:
-
Series:
-
Document Type:
-
Pages in Document:33 numbered pages
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
