i
Replicative Fitness of Seasonal Influenza A Viruses With Decreased Susceptibility to Baloxavir
-
1 14 2020
Source: J Infect Dis. 221(3):367-371 -
Alternative Title:J Infect Dis
-
Personal Author:
-
Description:Susceptibility of influenza A viruses to baloxavir can be affected by changes at amino acid residue 38 in the polymerase acidic (PA) protein. Information on replicative fitness of PA-I38-substituted viruses remains sparse. We demonstrated that substitutions I38L/M/S/T not only had a differential effect on baloxavir susceptibility (9- to 116-fold) but also on in vitro replicative fitness. Although I38L conferred undiminished growth, other substitutions led to mild attenuation. In a ferret model, control viruses outcompeted those carrying I38M or I38T substitutions, although their advantage was limited. These findings offer insights into the attributes of baloxavir-resistant viruses needed for informed risk assessment.
-
Subjects:
-
Source:
-
Pubmed ID:31541547
-
Pubmed Central ID:PMC8851376
-
Document Type:
-
Collection(s):
-
Main Document Checksum:
-
File Type:
Details:
Supporting Files
More +