Details:

Alternative Title:
J Infect Dis
Publisher's site:
http://dx.doi.org/10.1093/infdis/jiab390
Personal Author:
Winer, Rachel L. ; Lin, John ; Querec, Troy D. ; Unger, Elizabeth R. ; Stern, Joshua E. ; ... More +
Winer, Rachel L. ; Lin, John ; Querec, Troy D. ; Unger, Elizabeth R. ; Stern, Joshua E. ; Rudd, Jessica M. ; Golden, Matthew R. ; Swanson, Fred ; Markowitz, Lauri E. ; Meites, Elissa Less -
Description:
Background.

In the United States, human papillomavirus (HPV) vaccination has been recommended since 2011 for boys aged 11–12 years, with catch-up vaccination recommended through age 26 years for previously unvaccinated men who have sex with men (MSM).

Methods.

During 2016–2018, a cross-sectional study enrolled MSM and transgender women aged 18–26 years in Seattle, Washington. Participants submitted self-collected penile swab specimens for HPV genotyping. HPV vaccination history was self-reported. We compared HPV prevalence among vaccinated participants with that in participants with no or unknown vaccination history, using log-binomial regression to estimate adjusted prevalence ratios and confidence intervals.

Results.

Among 687 participants, 348 (50.7%) self-reported ever receiving ≥1 HPV vaccine dose; the median age at first HPV vaccination was 21 years, and the median age at first sex, 17 years. Overall, the prevalence of penile quadrivalent HPV vaccine (4vHPV)–type HPV was similar in vaccinated participants (12.1%) and participants with no or unknown vaccination (15.6%) (adjusted prevalence ratio, 0.69 [95% confidence interval, .47–1.01]). However, the prevalence was significantly lower in participants vaccinated at age ≤18 years than in those with no of unknown vaccination (0.15 [.04–.62]), corresponding to a vaccine effectiveness of 85% against 4vHPV-type HPV.

Conclusions.

Results suggest that HPV vaccination is effective in preventing penile HPV infections in young MSM when administered at age ≤18 years.


Subject:
[+]
Adolescent Alphapapillomavirus Cross-Sectional Studies Female Homosexuality, Male Humans Male Papillomaviridae Papillomavirus Infections Papillomavirus Vaccines Sexual And Gender Minorities Transgender Persons Vaccination
Source:
J Infect Dis. 225(3):422-430
Pubmed ID:
34320185
Pubmed Central ID:
PMC8842819
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U48 DP005013/DP/NCCDPHP CDC HHSUnited States/
CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U48 DP005013/DP/NCCDPHP CDC HHSUnited States/ Less -
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:c9795e1bceb5bdcfa38226f1ebf5f94aebfdc813dd025031fbf2c8d0ded05727
Download URL:
https://stacks.cdc.gov/view/cdc/114465/cdc_114465_DS1.pdf
File Type:

Supporting Files

• 	nihms-1776988-f0001.gif	gif
  	nihms-1776988-f0001.jpg	jpeg
  	nihms-1776988.nxml	xml

More +