Use of prescription medications associated with weight gain among US adults, 1999–2018: A nationally representative survey

Details

• Alternative Title:
  Obesity (Silver Spring)
• Personal Author:
  Hales, Craig M. ; Gu, Qiuping ; Ogden, Cynthia L. ; Yanovski, Susan Z.
• Description:
  Objective:
  
  This study aimed to evaluate trends in the use of obesogenic medications among adults.
  
  Methods:
  
  Cross-sectional data on adults aged ≥20 years are from the 1999 to 2018 National Health and Nutrition Examination Survey (n = 52,340). Obesogenic medications were defined according to the 2015 Endocrine Society guidelines on the pharmacological management of obesity. Weight status was categorized according to BMI. Trends in prior 30-day use were evaluated.
  
  Results:
  
  In NHANES 2017–2018, 20.3% of US adults used an obesogenic medication. Beta-blockers (9.8%) and antidiabetics (5.7%) were the most common; antipsychotics (1.0%) were the least common. Most common indications were disorders of glucose metabolism, hypertension, neuralgia or neuritis, heart disease, and musculoskeletal pain and/or inflammation. From 1999 to 2018, the proportional use of obesogenic medications increased for anticonvulsants (34.4% to 55.0%) but decreased for antidepressants (32.1% to 18.8%), antidiabetics (82.9% to 52.5%), and beta-blockers (83.9% to 80.7%). The proportional use of obesogenic medications was not associated with weight status, except for antipsychotics.
  
  Conclusions:
  
  Use of obesogenic medications was common. Differences in the proportional use of obesogenic medication may reflect changing availability of obesogenic versus nonobesogenic medications over time. The decision to prescribe a nonobesogenic alternative, if one exists, is guided by weighing the risks and benefits of available treatments.
  
  
• Subjects:
  Adult Article Cross-Sectional Studies Humans Nutrition Surveys Prescription Drugs United States Weight Gain Young Adult
• Source:
  Obesity (Silver Spring). 30(1):229-239
• Pubmed ID:
  34907655
• Pubmed Central ID:
  PMC8842491
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  30
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a9962adfd5288474e7fe2b164750ade430638771f699c0304e9476c318dd82d7
• Download URL:
  https://stacks.cdc.gov/view/cdc/114462/cdc_114462_DS1.pdf
• File Type:
  [PDF - 619.26 KB ]