Use of prescription medications associated with weight gain among US adults, 1999–2018: A nationally representative survey
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Use of prescription medications associated with weight gain among US adults, 1999–2018: A nationally representative survey

Filetype[PDF-619.26 KB]


  • English

  • Details:

    • Alternative Title:
      Obesity (Silver Spring)
    • Description:
      Objective:

      This study aimed to evaluate trends in the use of obesogenic medications among adults.

      Methods:

      Cross-sectional data on adults aged ≥20 years are from the 1999 to 2018 National Health and Nutrition Examination Survey (n = 52,340). Obesogenic medications were defined according to the 2015 Endocrine Society guidelines on the pharmacological management of obesity. Weight status was categorized according to BMI. Trends in prior 30-day use were evaluated.

      Results:

      In NHANES 2017–2018, 20.3% of US adults used an obesogenic medication. Beta-blockers (9.8%) and antidiabetics (5.7%) were the most common; antipsychotics (1.0%) were the least common. Most common indications were disorders of glucose metabolism, hypertension, neuralgia or neuritis, heart disease, and musculoskeletal pain and/or inflammation. From 1999 to 2018, the proportional use of obesogenic medications increased for anticonvulsants (34.4% to 55.0%) but decreased for antidepressants (32.1% to 18.8%), antidiabetics (82.9% to 52.5%), and beta-blockers (83.9% to 80.7%). The proportional use of obesogenic medications was not associated with weight status, except for antipsychotics.

      Conclusions:

      Use of obesogenic medications was common. Differences in the proportional use of obesogenic medication may reflect changing availability of obesogenic versus nonobesogenic medications over time. The decision to prescribe a nonobesogenic alternative, if one exists, is guided by weighing the risks and benefits of available treatments.

    • Pubmed ID:
      34907655
    • Pubmed Central ID:
      PMC8842491
    • Document Type:
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