Details:

Alternative Title:
Hematol Oncol Clin North Am
Publisher's site:
http://dx.doi.org/10.1016/j.hoc.2020.11.003
Personal Author:
Fleischman, Angela G ; Ramanathan, Gajalakshmi
Fleischman, Angela G ; Ramanathan, Gajalakshmi Less -
Description:
Chronic inflammation is a hallmark of myeloproliferative neoplasms (MPNs), with elevated levels of proinflammatory cytokines being commonly found in all 3 subtypes. Systemic inflammation is responsible for the constitutional symptoms, thrombosis risk, premature atherosclerosis, and disease evolution in MPN. Although the neoplastic clone and their differentiated progeny drive the inflammatory process, they also induce ancillary cytokine secretion from nonmalignant cells. Here, the authors describe the inflammatory milieu in MPN based on soluble factors and cellular mediators. They also discuss the prognostic value of cytokine measurements in patients with MPN and potential therapeutic strategies that target the cellular players in inflammation.
Subject:
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Cytokines Humans Myeloproliferative Disorders Neoplasms Prognosis Tumor Microenvironment
Source:
Hematol Oncol Clin North Am. 35(2):205-216
Pubmed ID:
33641864
Pubmed Central ID:
PMC8832361
Document Type:
Journal Article
Funding:
P30 CA062203/CA/NCI NIH HHSUnited States/ ; R01 CA077691/CA/NCI NIH HHSUnited States/ ; T32 CA009054/CA/NCI NIH HHSUnited States/ ; U01 IP000414/IP/NCIRD CDC HHSUnited States/
P30 CA062203/CA/NCI NIH HHSUnited States/ ; R01 CA077691/CA/NCI NIH HHSUnited States/ ; T32 CA009054/CA/NCI NIH HHSUnited States/ ; U01 IP000414/IP/NCIRD CDC HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:f07e20130ab0ef5712d1ee88180be1c03237c8ee0b467ad476e3662e05480f96
Download URL:
https://stacks.cdc.gov/view/cdc/114380/cdc_114380_DS1.pdf
File Type:

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