The Microenvironment in Myeloproliferative Neoplasms

Details

• Alternative Title:
  Hematol Oncol Clin North Am
• Personal Author:
  Fleischman, Angela G ; Ramanathan, Gajalakshmi
• Description:
  Chronic inflammation is a hallmark of myeloproliferative neoplasms (MPNs), with elevated levels of proinflammatory cytokines being commonly found in all 3 subtypes. Systemic inflammation is responsible for the constitutional symptoms, thrombosis risk, premature atherosclerosis, and disease evolution in MPN. Although the neoplastic clone and their differentiated progeny drive the inflammatory process, they also induce ancillary cytokine secretion from nonmalignant cells. Here, the authors describe the inflammatory milieu in MPN based on soluble factors and cellular mediators. They also discuss the prognostic value of cytokine measurements in patients with MPN and potential therapeutic strategies that target the cellular players in inflammation.
• Subjects:
  Article Cytokines Humans Inflammation Microenvironment Myeloid Cells Myeloproliferative Disorders Myeloproliferative Neoplasm Neoplasms Prognosis Tumor Microenvironment

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• Source:
  Hematol Oncol Clin North Am. 35(2):205-216
• Pubmed ID:
  33641864
• Pubmed Central ID:
  PMC8832361
• Document Type:
  Journal Article
• Funding:
  P30 CA062203/CA/NCI NIH HHSUnited States/ ; R01 CA077691/CA/NCI NIH HHSUnited States/ ; T32 CA009054/CA/NCI NIH HHSUnited States/ ; U01 IP000414/IP/NCIRD CDC HHSUnited States/
• Volume:
  35
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f07e20130ab0ef5712d1ee88180be1c03237c8ee0b467ad476e3662e05480f96
• Download URL:
  https://stacks.cdc.gov/view/cdc/114380/cdc_114380_DS1.pdf
• File Type:
  [PDF - 719.09 KB ]