Use of Recombinant Zoster Vaccine in Immunocompromised Adults Aged ≥19 Years: Recommendations of the Advisory Committee on Immunization Practices — U.S. 2022

Anderson, Tara C.; Masters, Nina B.; Guo, Angela; Shepersky, Leah; Leidner, Andrew J.; Lee, Grace M.; Kotton, Camille N.; Dooling, Kathleen L.

doi:10.15585/MMWRmm7103a2

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

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Use of Recombinant Zoster Vaccine in Immunocompromised Adults Aged ≥19 Years: Recommendations of the Advisory Committee on Immunization Practices — U.S. 2022

1 21 2022
By Anderson, Tara C. ; Masters, Nina B. ; Guo, Angela ; ...
Source: MMWR Morbidity Mortal Weekly Rep. 71(3):80-84
Series: Weekly Report: Morbidity and Mortality Weekly Report (MMWR)

[PDF-111.71 KB]

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Details:

Journal Article:

Morbidity and Mortality Weekly Report (MMWR)
Personal Author:

Anderson, Tara C. ; Masters, Nina B. ; Guo, Angela ; Shepersky, Leah ; Leidner, Andrew J. ; ... More +

Anderson, Tara C. ; Masters, Nina B. ; Guo, Angela ; Shepersky, Leah ; Leidner, Andrew J. ; Lee, Grace M. ; Kotton, Camille N. ; Dooling, Kathleen L. Less -
Description:

Zoster Vaccine Recombinant, Adjuvanted (Shingrix, GlaxoSmithKline [GSK]) is a 2-dose (0.5 mL each) subunit vaccine containing recombinant glycoprotein E in combination with adjuvant (AS01|) that was licensed in the U.S. for Prevention of herpes zoster for adults aged ≥50 years by the Food and Drug Administration (FDA) and recommended for immunocompetent adults aged ≥50 years by the Advisory Committee on Immunization Practices (ACIP) in 2017* (1). On July 23, 2021, the FDA expanded the indication for recombinant zoster vaccine (RZV) to include adults aged ≥18 years who are or will be at increased risk for herpes zoster because of immunodeficiency or immunosuppression caused by known disease or therapy (2). On October 20, 2021, ACIP recommended 2 doses of RZV for the Prevention of herpes zoster and related Complications in adults aged ≥19 years| who are or will be immunodeficient or immunosuppressed because of disease or therapy. RZV is the first herpes zoster vaccine approved for use in immunocompromised persons. With moderate to high vaccine efficacy and an acceptable safety profile, RZV has the potential to prevent considerable herpes zoster incidence and related Complications. This report updates previous ACIP Rec.for the Prevention of herpes zoster (1,3).
Subjects:

[+]

Adult Advisory Committees Drug Approval Herpes Zoster Herpes Zoster Vaccine Humans Immunocompromised Host Middle Aged Vaccines, Synthetic
Source:

MMWR Morbidity Mortal Weekly Rep. 71(3):80-84
Series:

Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
DOI:

http://dx.doi.org/10.15585/MMWRmm7103a2
ISSN:

0149-2195 (print);1545-861X (digital);
Pubmed ID:

35051134
Pubmed Central ID:

PMC8774159
Document Type:

Journal Article
Name as Subject:

U.S. Food and Drug Administration.
Place as Subject:

U.S.
Pages in Document:

5 pdf pages
Volume:

71
Issue:

3
Collection(s):

Morbidity and Mortality Weekly Report (MMWR)
Main Document Checksum:

[+]

urn:sha-512:1ad647f2e4a9d93746959df3765cda8b05524b2f2b0b2e487a0fa77f3be1714694f5c74dd516df14285b84678729b1faacfd3c87e373984ba5ec1f5e94e5e32d
Download URL:

https://stacks.cdc.gov/view/cdc/114308/cdc_114308_DS1.pdf
File Type:

mm7103a2.nxml

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