Medications for opioid use disorder associated with less against medical advice discharge among persons who inject drugs hospitalized with an invasive infection

Details

• Alternative Title:
  J Addict Med
• Personal Author:
  Nolan, Nathanial S. ; Marks, Laura R. ; Liang, Stephen Y. ; Durkin, Michael J.
• Description:
  Objectives:
  
  To identify the incidence, characteristics and factors associated with against medical advice (AMA) discharge among hospitalized patients with opioid use disorder (OUD) and injection related infections (e.g., endocarditis, osteomyelitis, epidural abscesses).
  
  Methods:
  
  This retrospective cohort study evaluated adults with OUD admitted to an academic medical center from 1/1/2016-7/1/2019 for an invasive injection related infection. Multivariable logistic regression was used to determine independent factors associated with AMA discharge.
  
  Results:
  
  Among 262 adults admitted with serious injection related infections and comorbid OUD, 138 received inpatient medications for opioid use disorder (MOUD). Univariate analysis showed a decreased odds ratio (OR) of AMA discharge when patients received MOUD inpatient (OR 0.55; 95% CI 0.34-0.91.). Adjusting for covariates associated with social determinants of health and other substance use, inpatient receipt of MOUD was associated with a decreased risk of AMA discharge (adjusted OR 0.49; 95% CI 0.028 – 0.84).
  
  Conclusions:
  
  Among patients with OUD and serious injection related infections, inpatient initiation of MOUD is associated with decreased risk of AMA discharge.
  
  
• Subjects:
  Adult Article Drug Users Endocarditis Humans Opioid-Related Disorders Opioid Use Disorder Osteomyelitis Patient Discharge Persons Who Inject Drugs Pharmaceutical Preparations Retrospective Studies Substance Abuse, Intravenous

  More +
• Source:
  J Addict Med. 15(2):155-158
• Pubmed ID:
  32804690
• Pubmed Central ID:
  PMC7995266
• Document Type:
  Journal Article
• Funding:
  KL2 TR002346/TR/NCATS NIH HHSUnited States/ ; L30 AI133778/AI/NIAID NIH HHSUnited States/ ; T32 AI007172/AI/NIAID NIH HHSUnited States/ ; U54 CK000609/CK/NCEZID CDC HHSUnited States/
• Volume:
  15
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:db9a50e65284aa7212d266ee2782ac54108c2f06c53af25be26d6c84a896d324
• Download URL:
  https://stacks.cdc.gov/view/cdc/114232/cdc_114232_DS1.pdf
• File Type:
  [PDF - 55.54 KB ]