Clinical Characteristics and Outcomes Among Adults Hospitalized with Laboratory-confirmed SARS-CoV-2 Infection During Periods of B.1.617.2 (Delta) and B.1.1.529 (Omicron) Variants Predominance — One Hospital, California, July 15–September 23, 2021, and December 21, 2021–January 27, 2022

Details

• Personal Author:
  Modes, Matthew E. ; Directo, Michael P. ; Melgar, Michael ; Johnson, Lily R. ; Yang, Haoshu ; Chaudhary, Priya ; Bartolini, Susan ; Kho, Norling ; Noble, Paul W. ; Isonaka, Sharon ; Chen, Peter
• Corporate Authors:
  Cedars-Sinai Medical Center ; Women’s Guild Lung Institute ; CDC COVID-19 Emergency Response Team
• Description:
  What is already known about this topic? The SARS-CoV-2 Omicron Variants became predominant in the U.S. in mid-December 2021, coinciding with a rise in SARS-CoV-2–associated hospitalizations.
  
  What is added by this report? Among adults hospitalized with SARS-CoV-2 infection during Omicron predominance, COVID-19 vaccination, including with a booster dose, was associated with lower likelihood of intensive care unit admission. Compared with patients during the period of Delta predominance, Omicron-period patients had less severe illness, largely driven by an increased proportion who were fully vaccinated. Approximately 20% of early Omicron-period hospitalizations were for non–COVID-19 conditions, particularly among young and vaccinated adults.
  
  What are the implications for public health practice? COVID-19 vaccination, particularly a booster dose, continues to be critical in mitigating the health care burden of the Omicron Variants.
  
  Suggested citation for this article: Modes ME, Directo MP, Melgar M, et al. Clinical Characteristics and Outcomes Among Adults Hospitalized with Laboratory-Confirmed SARS-CoV-2 Infection During Periods of B.1.617.2 (Delta) and B.1.1.529 (Omicron) Variant Predominance — One Hospital, California, July 15–September 23, 2021, and December 21, 2021–January 27, 2022. MMWR Morb Mortal Wkly Rep. ePub: 4 February 2022.
  
  mm7106e2.htm?s_cid=mm7106e2_w
  
  mm7106e2-H.pdf
  
  
• Subjects:
  Adolescent Adult Aged CoronaVirus Infections COVID-19 Female Hospitalization Humans Male Middle Aged SARS-CoV-2 Severity Of Illness Index Young Adult

  More +
• Source:
  MMWR: Morbidity and Mortality Weekly Report 2022; v. 71 Early Release
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Document Type:
  Journal Article
• Place as Subject:
  Los Angeles, CA
• Pages in Document:
  7 pdf pages
• Volume:
  71
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:7693af587a8f6cc6c989472178f42321d0e46c237dad12690a3f17f9e005bb64e3003821cb2d9f14e49a3cd00a750f037e3b0cc93bc0f7b6ff6e2e288a8b2ebd
• Download URL:
  https://stacks.cdc.gov/view/cdc/114166/cdc_114166_DS1.pdf
• File Type:
  [PDF - 396.12 KB ]