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Clinical characteristics and outcomes among adults hospitalized with laboratory-confirmed SARS-CoV-2 infection during periods of B.1.617.2 (Delta) and B.1.1.529 (Omicron) Variants predominance — one hospital, California, July 15–September 23, 2021, and December 21, 2021–January 27, 2022
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February 4, 2022
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Series: MMWR; v. 71, ER, 2/4/22
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Description:What is already known about this topic? The SARS-CoV-2 Omicron Variants became predominant in the U.S. in mid-December 2021, coinciding with a rise in SARS-CoV-2–associated hospitalizations.
What is added by this report? Among adults hospitalized with SARS-CoV-2 infection during Omicron predominance, COVID-19 vaccination, including with a booster dose, was associated with lower likelihood of intensive care unit admission. Compared with patients during the period of Delta predominance, Omicron-period patients had less severe illness, largely driven by an increased proportion who were fully vaccinated. Approximately 20% of early Omicron-period hospitalizations were for non–COVID-19 conditions, particularly among young and vaccinated adults.
What are the implications for public health practice? COVID-19 vaccination, particularly a booster dose, continues to be critical in mitigating the health care burden of the Omicron Variants.
Suggested citation for this article: Modes ME, Directo MP, Melgar M, et al. Clinical Characteristics and Outcomes Among Adults Hospitalized with Laboratory-Confirmed SARS-CoV-2 Infection During Periods of B.1.617.2 (Delta) and B.1.1.529 (Omicron) Variant Predominance — One Hospital, California, July 15–September 23, 2021, and December 21, 2021–January 27, 2022. MMWR Morb Mortal Wkly Rep. ePub: 4 February 2022.
mm7106e2.htm?s_cid=mm7106e2_w
mm7106e2-H.pdf
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Pages in Document:7 numbered pages
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Volume:71
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