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Impact of Timing of Antiretroviral Treatment and Birth Weight on Mother-to-Child Human Immunodeficiency Virus Transmission: Findings From an 18-Month Prospective Cohort of a Nationally Representative Sample of Mother–Infant Pairs During the Transition From Option A to Option B+ in Zimbabwe
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2 01 2018
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Source: Clin Infect Dis. 66(4):576-585
Details:
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Alternative Title:Clin Infect Dis
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Personal Author:
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Description:Background.
Preventing mother-to-child transmission of human immunodeficiency virus transmission (MTCT) depends on early initiation of antiretroviral therapy (ART). We report the 18-month MTCT risk during the transition from Option A to Option B+ in Zimbabwe, and assess whether ART preconception could eliminate MTCT in breastfeeding populations.
Methods.
In 2013, we consecutively recruited a nationally representative sample of 6051 infants aged 4–12 weeks and their mothers from 151 immunization clinics using a multistage stratified cluster sampling method. We identified 1172 human immunodeficiency virus (HIV)–exposed infants and evaluated them at baseline and every 3 months until the child became HIV-infected, died, or reached age 18 months.
Results.
The cumulative MTCT risk through 18 months postdelivery was 7.0%. Of the HIV-infected mothers, 35.3% started ART preconception, 28.9% during pregnancy, and 9.7% after delivery, and 16.0% received zidovudine during pregnancy. Compared to mothers without antiretroviral drug use, MTCT among those starting ART preconception and during pregnancy was lower by 88% (adjusted hazard ratio [aHR], 0.12; 95% confidence interval [CI], .06–.24) and 75% (aHR, 0.25; 95% CI, .14–.45), respectively. HIV-exposed infants with birth weight <2.5 kg (low birth weight) were 2.6-fold more likely to acquire HIV infection compared to those with birth weight ≥2.5 kg (aHR, 2.57; 95% CI, 1.44–4.59). Controlling for other factors, breastfeeding was not significantly associated with MTCT.
Conclusions.
ART preconception has the highest impact on reducing MTCT, indicating that HIV-infected, reproductive-age women should be prioritized in “treat-all” strategies. HIV-infected mothers without ART use should be identified at the first immunization visit and treatment initiated to reduce postdelivery MTCT. MTCT risk is higher in mothers with low-birth-weight deliveries.
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Pubmed ID:29401270
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Pubmed Central ID:PMC8764936
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Volume:66
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Issue:4
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[PDF-1.10 MB]
