Systematic Genomic and Clinical Analysis of Severe Acute Respiratory Syndrome Coronavirus 2 Reinfections and Recurrences Involving the Same Strain

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Rodríguez-Grande, Cristina ; Alcalá, Luis ; Estévez, Agustín ; Sola-Campoy, Pedro J. ; Buenestado-Serrano, Sergio ; Martínez-Laperche, Carolina ; Manuel de la Cueva, Víctor ; Alonso, Roberto ; Andrés-Zayas, Cristina ; Adán-Jiménez, Javier ; Losada, Carmen ; Rico-Luna, Carla ; Comas, Iñaki ; González-Candelas, Fernando ; Catalán, Pilar ; Muñoz, Patricia ; Pérez-Lago, Laura ; de Viedma, Darío García
• Corporate Authors:
  on behalf of the Gregorio Marañón Microbiology-ID COVID 19 Study Group2
• Description:
  Estimates of the burden of severe acute respiratory syndrome coronavirus 2 reinfections are limited by the scarcity of population-level studies incorporating genomic support. We conducted a systematic study of reinfections in Madrid, Spain, supported by genomic viral analysis and host genetic analysis, to cleanse laboratory errors and to discriminate between reinfections and recurrences involving the same strain. Among the 41,195 cases diagnosed (March 2020-March 2021), 93 (0.23%) had 2 positive reverse transcription PCR tests (55-346 days apart). After eliminating cases with specimens not stored, of suboptimal sequence quality, or belonging to different persons, we obtained valid data from 22 cases. Of those, 4 (0.01%) cases were recurrences involving the same strain; case-patients were 39-93 years of age, and 3 were immunosuppressed. Eighteen (0.04%) cases were reinfections; patients were 19-84 years of age, and most had no relevant clinical history. The second episode was more severe in 8 cases.
• Subjects:
  Child, Preschool Coronavirus Infections Covid-19 Genomics Humans Polymerase Chain Reaction Reinfection Sars-Cov-2
• Source:
  Emerg Infect Dis. 2022; 28(1):85-94
• Pubmed ID:
  34843661
• Pubmed Central ID:
  PMC8714233
• Document Type:
  Journal Article
• Place as Subject:
  Spain
• Volume:
  28
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:457dd6827b16d8418e4fbe6c4ee970e6a6053f71171d89ae2a8c637439cca12c
• Download URL:
  https://stacks.cdc.gov/view/cdc/113353/cdc_113353_DS1.pdf
• File Type:
  [PDF - 1.88 MB ]