Cost-effectiveness of seasonal inactivated influenza vaccination among pregnant women

Details

• Alternative Title:
  Vaccine
• Personal Author:
  Xu, Jing ; Zhou, Fangjun ; Reed, Carrie ; Chaves, Sandra S. ; Messonnier, Mark ; Kim, Inkyu K.
• Description:
  Objective:
  
  To evaluate the cost-effectiveness of seasonal inactivated influenza vaccination among pregnant women using data from three recent influenza seasons in the United States.
  
  Design, setting, and participants:
  
  We developed a decision-analytic model following a cohort of 5.2 million pregnant women and their infants aged <6 months to evaluate the cost-effectiveness of vaccinating women against seasonal influenza during pregnancy from a societal perspective. The main outcome measures were quality-adjusted life-year (QALY) gained and cost-effectiveness ratios. Data sources included surveillance data, epidemiological studies, and published vaccine cost data. Sensitivity analyses were also performed. All costs and outcomes were discounted at 3% annually.
  
  Main outcome measures:
  
  Total costs (direct and indirect), effects (QALY gains, averted case numbers), and incremental cost-effectiveness of seasonal inactivated influenza vaccination among pregnant women (cost per QALY gained).
  
  Results:
  
  Using a recent benchmark of 52.2% vaccination coverage among pregnant women, we studied a hypothetical cohort of 2,753,015 vaccinated pregnant women. With an estimated vaccine effectiveness of 73% among pregnant women and 63% among infants <6 months, QALY gains for each season were 305 (2010–2011), 123 (2011–2012), and 610 (2012–2013). Compared with no vaccination, seasonal influenza vaccination during pregnancy was cost-saving when using data from the 2010–2011 and 2012–2013 influenza seasons. The cost-effectiveness ratio was greater than $100,000/QALY with the 2011–2012 influenza season data, when CDC reported a low attack rate compared to other recent seasons.
  
  Conclusions:
  
  Influenza vaccination for pregnant women can reduce morbidity from influenza in both pregnant women and their infants aged <6 months. Seasonal influenza vaccination during pregnancy is cost-saving during moderate to severe influenza seasons.
  
  
• Subjects:
  Article Cost-Benefit Analysis Cost-effectiveness Analysis Female Humans Infant Infant, Newborn Influenza, Human Influenza Vaccines Models, Statistical Pregnancy Quality-Adjusted Life Years Seasonal Influenza Vaccination United States Vaccination

  More +
• Source:
  Vaccine. 34(27):3149-3155
• Pubmed ID:
  27161997
• Pubmed Central ID:
  PMC8721743
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  34
• Issue:
  27
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:388265271eeeaf4c034a13648f7da81e1a63236b17568d686db5737607ea2b0f
• Download URL:
  https://stacks.cdc.gov/view/cdc/113053/cdc_113053_DS1.pdf
• File Type:
  [PDF - 394.36 KB ]