Demographic and epidemiological characteristics associated with reduced antimicrobial susceptibility to Neisseria gonorrhoeae in the United States, Strengthening the U.S. Response to Resistant Gonorrhea (SURRG), 2018–2019

Details

• Alternative Title:
  Sex Transm Dis
• Personal Author:
  Gieseker, Karen ; Learner, Emily R. ; Mauk, Kerry ; Barbee, Lindley A. ; McNeil, Candice J. ; Hasty, Gerald L. ; Black, Jamie M. ; Johnson, Kimberly ; Nguyen, Trang Quyen ; Shrestha, Dhana ; Pham, Cau D. ; St. Cyr, Sancta ; Schlanger, Karen ; Kirkcaldy, Robert D.
• Corporate Authors:
  SURRG Working Group
• Description:
  Background:
  
  Jurisdictions participating in Strengthening the United States Response to Resistant Gonorrhea (SURRG) implemented specimen collection for culture and antimicrobial susceptibility testing (AST) from a sample of persons of all genders (at multiple anatomic sites) attending STD clinics and community clinics. We describe the percentage and characteristics of patients whose isolates demonstrated reduced susceptibility (RS) to azithromycin, ceftriaxone, or cefixime.
  
  Methods:
  
  We included patients from clinics that participated in SURRG whose isolates underwent AST by Etest. We defined RS as azithromycin minimum inhibitory concentrations (MICs) ≥2 μg/ml (AZM-RS), ceftriaxone MICs ≥0.125 μg/ml (CRO-RS), or cefixime MICs ≥0.25 μg/ml (CFX-RS). Patients with repeated infections appeared >1 time in the data. We calculated the frequency and percentage of patients with an isolate demonstrating RS by epidemiological characteristics.
  
  Results:
  
  During 2018–2019, 10,013 patients from eight jurisdictions provided 10,735 isolates. Among 10,013 patients, 11.0% (n=1,099) had ≥1 isolate with AZM-RS (range by jurisdiction 2.5%–18.0%). Approximately 11.3% of 8,771 of patients visiting STD clinics and approximately 8.8% of 1,242 patients visiting community clinics had an AZM-RS isolate. Nearly 6% of 1,013 females had an AZM-RS isolate; among males, the percent of patients with an AZM-RS isolate was 17.7% among 4,177 men who have sex only with men and 6.1% among 3,581 men who have sex only with women. Few (0.4%) patients had isolates with CFX-RS (n=40) or CRO-RS (n=43).
  
  Conclusions:
  
  Although infections with reduced cephalosporin susceptibility were rare, AZM-RS infections were prevalent in this sample of patients in multiple jurisdictions and across gender and gender of sex partner categories.
  
  Short Summary:
  
  Data from SURRG demonstrated that 11% of sampled patients attending STD clinics and community clinics had an isolate with reduced azithromycin susceptibility; <1% had reduced cephalosporin susceptibility.
  
  
• Subjects:
  Anti-Bacterial Agents Azithromycin Ceftriaxone Demography Drug Resistance, Bacterial Female Gonorrhea Humans Male Microbial Sensitivity Tests Neisseria Gonorrhoeae United States

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• Source:
  Sex Transm Dis. 48(12 ):S118-S123
• Pubmed ID:
  34433798
• Pubmed Central ID:
  PMC8711092
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  48
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:e30c5a166c850069860e5148b1fccc58c533626ca5028dec5f4fcb5e44e4871d440441bf789577103850483cf267134a01e7b8e76d52e0789a82c33867d5ae2f
• Download URL:
  https://stacks.cdc.gov/view/cdc/112958/cdc_112958_DS1.pdf
• File Type:
  [PDF - 92.03 KB ]