Details:

Alternative Title:
Occup Environ Med
Publisher's site:
http://dx.doi.org/10.1136/oemed-2020-106715
Personal Author:
Shrestha, Deepika ; Picciotto, Sally ; LaValley, Michael P. ; Liu, Sa ; Hammond, S. Katharine ; ... More +
Shrestha, Deepika ; Picciotto, Sally ; LaValley, Michael P. ; Liu, Sa ; Hammond, S. Katharine ; Weiner, Daniel E. ; Eisen, Ellen A. ; Applebaum, Katie M. ; Less -
Description:
Objective. Despite increasing prevalence of end-stage renal disease (ESRD), little attention has been directed to how occupational exposures may contribute to risk. Our objective was to investigate the relationship between metalworking fluids (MWF) and ESRD in a cohort of 36,703 male autoworkers. Methods. We accounted for competing risk of death, using the subdistribution hazard approach to estimate subhazard ratios (sHRs) and 95% confidence intervals (CIs) in models with cubic splines for cumulative exposure to MWF (straight, soluble, or synthetic). Results. Based on 501 ESRD cases and 13,434 deaths, we did not observe an association between MWF and ESRD overall. We observed modest associations between MWF and ESRD classification of glomerulonephritis and diabetic nephropathy. For glomerulonephritis, the 60th percentile of straight MWF was associated with an 18% increased subhazard (sHR=1.18, 95% CI (0.99, 1.41)). For diabetic nephropathy, the subhazard increased 28% at the 60th percentile of soluble MWF (sHR=1.28, 95% CI (1.00, 1.64)). Differences by race suggest that Black males may have higher disease rates following MWF exposure. Conclusions. Exposure to straight and soluble MWF may be related to ESRD classification, though this relationship should be further examined.
Subject:
[+]
Adult
Aged
Cohort Studies
Diabetic Nephropathies
Glomerulonephritis
Humans
Industrial Oils
Kidney Failure, Chronic
Male
Manufacturing And Industrial Facilities
Metal Workers
Middle Aged
Occupational Diseases
Occupational Exposure
Particulate Matter

Source:
Occup Environ Med. 79(1):24-31 ;
Pubmed ID:
34210793
Pubmed Central ID:
PMC8678287
Document Type:
Journal Article ;
Funding:
R01 OH010028/OH/NIOSH CDC HHSUnited States/ ; R01 OH010180/OH/NIOSH CDC HHSUnited States/ ;
R01 OH010028/OH/NIOSH CDC HHSUnited States/ ; R01 OH010180/OH/NIOSH CDC HHSUnited States/ ; Less -
Place as Subject:
Michigan ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:c1236bca8740a643427bfccb03ef50d0dfa5ed0e5346310b399ddf438359011e
File Type:

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