Risk for Stillbirth Among Women With and Without COVID-19 at Delivery Hospitalization — U.S. March 2020–September 2021

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  DeSisto, Carla L. ; Wallace, Bailey ; Simeone, Regina M. ; Polen, Kara ; Ko, Jean Y. ; Meaney-Delman, Dana ; Ellington, Sascha R.
• Description:
  Pregnant women are at increased risk for severe COVID-19-related illness, and COVID-19 is associated with an increased risk for adverse pregnancy outcomes and maternal and neonatal Complications (1-3). To date, studies assessing whether COVID-19 during pregnancy is associated with increased risk for stillbirth have yielded mixed results (2-4). Since the B.1.617.2 (Delta) Variants of SARS-CoV-2 (the Virus that causes COVID-19) became the predominant circulating Variants,* there have been anecdotal reports of increasing rates of stillbirths in women with COVID-19.| CDC used the Premier Healthcare Database Special COVID-19 Release (PHD-SR), a large hospital-based administrative database,| to assess whether a maternal COVID-19 Diagnosis documented at delivery hospitalization was associated with stillbirth during March 2020-September 2021 as well as before and during the period of Delta Variants predominance in the U.S. (March 2020-June 2021 and July-September 2021, respectively). Among 1,249,634 deliveries during March 2020-September 2021, stillbirths were rare (8,154; 0.65%): 273 (1.26%) occurred among 21,653 deliveries to women with COVID-19 documented at the delivery hospitalization, and 7,881 (0.64%) occurred among 1,227,981 deliveries without COVID-19. The adjusted risk for stillbirth was higher in deliveries with COVID-19 compared with deliveries without COVID-19 during March 2020-September 2021 (adjusted relative risk [aRR] = 1.90; 95% CI = 1.69-2.15), including during the pre-Delta (aRR = 1.47; 95% CI = 1.27-1.71) and Delta periods (aRR = 4.04; 95% CI = 3.28-4.97). COVID-19 documented at delivery was associated with increased risk for stillbirth, with a stronger association during the period of Delta Variants predominance. Implementing evidence-based COVID-19 Prevention strategies, including vaccination before or during pregnancy, is critical to reducing the impact of COVID-19 on stillbirths.
• Subjects:
  Adult CoronaVirus Infections COVID-19 Delivery, Obstetric Female Hospitalization Humans Pregnancy Pregnancy Complications, Infectious Risk Assessment Stillbirth

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• Source:
  MMWR Morbidity Mortal Weekly Rep. 70(47):1640-1645
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/MMWRmm7047e1
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  34818318
• Pubmed Central ID:
  PMC8612508
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  6 pdf pages
• Volume:
  70
• Issue:
  47
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:575beb5f3d39e0c051a4bc7f5efabbacf6cf7d8b5b7f73b6410867f54c571086213f0a611c3ae9b58dd07ff7322fef22490de308eedd549080a7b5c459b8ad4f
• Download URL:
  https://stacks.cdc.gov/view/cdc/112527/cdc_112527_DS1.pdf
• File Type:
  [PDF - 162.95 KB ]