Enterovirus D68-Associated Acute Respiratory Illness ─ New Vaccine Surveillance Network, U.S. July–November 2018–2020

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Shah, Melisa M. ; Perez, Ariana ; Lively, Joana Y. ; Avadhanula, Vasanthi ; Boom, Julie A. ; Chappell, James ; Englund, Janet A. ; Fregoe, Wende ; Halasa, Natasha B. ; Harrison, Christopher J. ; Hickey, Robert W. ; Klein, Eileen J. ; McNeal, Monica M. ; Michaels, Marian G. ; Moffatt, Mary E. ; Otten, Catherine ; Sahni, Leila C. ; Schlaudecker, Elizabeth ; Schuster, Jennifer E. ; Selvarangan, Rangaraj ; Staat, Mary A. ; Stewart, Laura S. ; Weinberg, Geoffrey A. ; Williams, John V. ; Ng, Terry Fan Fei ; Routh, Janell A. ; Gerber, Susan I. ; McMorrow, Meredith L. ; Rha, Brian ; Midgley, Claire M.
• Description:
  EnteroVirus D68 (EV-D68) is associated with a broad spectrum of illnesses, including mild to severe acute respiratory illness (ARI) and acute flaccid myelitis (AFM). EnteroViruses, including EV-D68, are typically detected in the U.S. during late summer through fall, with year-to-year fluctuations. Before 2014, EV-D68 was infrequently reported to CDC (1). However, numbers of EV-D68 detection have increased in recent years, with a biennial pattern observed during 2014-2018 in the U.S. after the expansion of Surveillance and wider availability of molecular tTesting. In 2014, a national outbreak of EV-D68 was detected (2). EV-D68 was also reported in 2016 via local (3) and passive national (4) Surveillance EV-D68 detections were limited in 2017, but substantial circulation was observed in 2018 (5). To assess recent levels of circulation, EV-D68 detections in respiratory specimens collected from patients aged <18 years* with ARI evaluated in emergency departments (EDs) or admitted to one of seven U.S. medical centers| within the New Vaccine Surveillance Network (NVSN) were summarized. This report provides a provisional description of EV-D68 detections during July-November in 2018, 2019 and 2020, and describes the demographic and clinical characteristics of these patients. In 2018, a total of 382 EV-D68 detections in respiratory specimens obtained from patients aged <18 years with ARI were reported by NVSN; the number decreased to six detections in 2019 and 30 in 2020. Among patients aged <18 years with EV-D68 in 2020, 22 (73%) were non-Hispanic Black (Black) persons. EV-D68 detections in 2020 were lower than anticipated based on the biennial circulation pattern observed since 2014. The circulation of EV-D68 in 2020 might have been limited by widespread COVID-19 mitigation measures; how these changes in behavior might influence the timing and levels of circulation in future years is unknown. Ongoing monitoring of EV-D68 detections is warranted for preparedness for EV-D68-associated ARI and AFM.
• Subjects:
  Adolescent Child Child, Preschool Disease Outbreaks EnteroVirus D, Human EnteroVirus Infections Female Humans Infant Male Population Surveillance Respiratory Tract Infections

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• Source:
  MMWR Morbidity Mortal Weekly Rep. 70(47):1623-1628
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/MMWRmm7047a1
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  34818320
• Pubmed Central ID:
  PMC8612514
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  6 pdf pages
• Volume:
  70
• Issue:
  47
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:2fa78f310b00fb1ea3954569084613cd6bbed66b5abb9d13afc25d8cd8f3e58d5e26348400e4374d2e297bf2fa88baa23c975b32eeba0ee3f14759f125ed1f70
• Download URL:
  https://stacks.cdc.gov/view/cdc/112522/cdc_112522_DS1.pdf
• File Type:
  [PDF - 177.73 KB ]