Laboratory-Confirmed COVID-19 Among Adults Hospitalized with COVID-19–Like Illness with Infection-Induced or mRNA Vaccine-Induced SARS-CoV-2 Immunity — Nine States, January–September 2021

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Bozio, Catherine H. ; Grannis, Shaun J. ; Naleway, Allison L. ; Ong, Toan C. ; Butterfield, Kristen A. ; DeSilva, Malini B. ; Natarajan, Karthik ; Yang, Duck-Hye ; Rao, Suchitra ; Klein, Nicola P. ; Irving, Stephanie A. ; Dixon, Brian E. ; Dascomb, Kristin ; Liao, I-Chia ; Reynolds, Sue ; McEvoy, Charlene ; Han, Jungmi ; Reese, Sarah E. ; Lewis, Ned ; Fadel, William F. ; Grisel, Nancy ; Murthy, Kempapura ; Ferdinands, Jill ; Kharbanda, Anupam B. ; Mitchell, Patrick K. ; Goddard, Kristin ; Embi, Peter J. ; Arndorfer, Julie ; Raiyani, Chandni ; Patel, Palak ; Rowley, Elizabeth A. ; Fireman, Bruce ; Valvi, Nimish R. ; Griggs, Eric P. ; Levy, Matthew E. ; Zerbo, Ousseny ; Porter, Rachael M. ; Birch, Rebecca J. ; Blanton, Lenee ; Ball, Sarah W. ; Steffens, Andrea ; Olson, Natalie ; Williams, Jeremiah ; Dickerson, Monica ; McMorrow, Meredith ; Schrag, Stephanie J. ; Verani, Jennifer R. ; Fry, Alicia M. ; Azziz-Baumgartner, Eduardo ; Barron, Michelle ; Gaglani, Manjusha ; Thompson, Mark G. ; Stenehjem, Edward
• Description:
  Previous infection with SARS-CoV-2 (the Virus that causes COVID-19) or COVID-19 vaccination can provide immunity and protection from subsequent SARS-CoV-2 infection and illness. CDC used data from the VISION Network* to examine hospitalizations in adults with COVID-19-like illness and compared the odds of receiving a positive SARS-CoV-2 test result, and thus having laboratory-confirmed COVID-19, between unvaccinated patients with a previous SARS-CoV-2 infection occurring 90-179 days before COVID-19-like illness hospitalization, and patients who were fully vaccinated with an mRNA COVID-19 vaccine 90-179 days before hospitalization with no previous documented SARS-CoV-2 infection. Hospitalized adults aged ≥18 years with COVID-19-like illness were included if they had received tTesting at least twice: once associated with a COVID-19-like illness hospitalization during January-September 2021 and at least once earlier (since February 1, 2020, and ≥14 days before that hospitalization). Among COVID-19-like illness hospitalizations in persons whose previous infection or vaccination occurred 90-179 days earlier, the odds of laboratory-confirmed COVID-19 (adjusted for sociodemographic and health characteristics) among unvaccinated, previously infected adults were higher than the odds among fully vaccinated recipients of an mRNA COVID-19 vaccine with no previous documented infection (adjusted odds ratio [aOR] = 5.49; 95% confidence interval [CI] = 2.75-10.99). These findings suggest that among hospitalized adults with COVID-19-like illness whose previous infection or vaccination occurred 90-179 days earlier, vaccine-induced immunity was more protective than infection-induced immunity against laboratory-confirmed COVID-19. All eligible persons should be vaccinated against COVID-19 as soon as possible, including unvaccinated persons previously infected with SARS-CoV-2.
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over CoronaVirus Infections COVID-19 COVID-19 Vaccines Female Hospitalization Humans Laboratories Male Middle Aged SARS-CoV-2 Vaccines, Synthetic Young Adult

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• Source:
  MMWR Morbidity Mortal Weekly Rep. 70(44):1539-1544
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/MMWRmm7044e1
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  34735425
• Pubmed Central ID:
  PMC8568091
• Document Type:
  Journal Article
• Pages in Document:
  6 pdf pages
• Volume:
  70
• Issue:
  44
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:cc6d17e40a98d63ade1e58c6df62e4472d24b85bb82b924103a52714226b59d715571eefd8bb9d7eb147d2d880b3d7b5759cb0d8a3dbdbeab8985428b4a1f92b
• Download URL:
  https://stacks.cdc.gov/view/cdc/111848/cdc_111848_DS1.pdf
• File Type:
  [PDF - 128.17 KB ]