Severity of Disease Among Adults Hospitalized with Laboratory-Confirmed COVID-19 Before and During the Period of SARS-CoV-2 B.1.617.2 (Delta) Predominance — COVID-NET, 14 States, January–August 2021

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Taylor, Christopher A. ; Patel, Kadam ; Pham, Huong ; Whitaker, Michael ; Anglin, Onika ; Kambhampati, Anita K. ; Milucky, Jennifer ; Chai, Shua J. ; Kirley, Pam Daily ; Alden, Nisha B. ; Armistead, Isaac ; Meek, James ; Yousey-Hindes, Kimberly ; Anderson, Evan J. ; Openo, Kyle P. ; Teno, Kenzie ; Weigel, Andy ; Monroe, Maya L. ; Ryan, Patricia A. ; Henderson, Justin ; Nunez, Val Tellez ; Bye, Erica ; Lynfield, Ruth ; Poblete, Mayvilynne ; Smelser, Chad ; Barney, Grant R. ; Spina, Nancy L. ; Bennett, Nancy M. ; Popham, Kevin ; Billing, Laurie M. ; Shiltz, Eli ; Abdullah, Nasreen ; Sutton, Melissa ; Schaffner, William ; Talbot, H. Keipp ; Ortega, Jake ; Price, Andrea ; Garg, Shikha ; Havers, Fiona P. ; Roland, Jeremy ; Blythe, David ; Brooks, Alicia ; Como-Sabetti, Kathryn ; Danila, Richard ; Judson, Melissa ; Omondi, Wickliffe ; Engesser, Kerianne ; Rowe, Adam ; Gaitán, Maria ; Cafferky, Virginia ; Freshwater, Julie ; Salvator, Ann ; Hawkins, Sam ; Youngers, Emily ; Markus, Tiffanie ; Crossland, Melanie ; McCaffrey, Keegan
• Corporate Authors:
  COVID-NET Surveillance Team
• Description:
  In mid-June 2021, B.1.671.2 (Delta) became the predominant Variants of SARS-CoV-2, the Virus that causes COVID-19, circulating in the U.S. As of July 2021, the Delta Variants was responsible for nearly all new SARS-CoV-2 infections in the U.S.* The Delta Variants is more transmissible than previously circulating SARS-CoV-2 Variantss (1); however, whether it causes more severe disease in adults has been uncertain. Data from the CDC COVID-19-Associated Hospitalization Surveillance Network (COVID-NET), a population-based Surveillance system for COVID-19-associated hospitalizations, were used to examine Trends in severe outcomes in adults aged ≥18 years hospitalized with laboratory-confirmed COVID-19 during periods before (January-June 2021) and during (July-August 2021) Delta Variants predominance. COVID-19-associated hospitalization rates among all adults declined during January-June 2021 (pre-Delta period), before increasing during July-August 2021 (Delta period). Among sampled nonpregnant hospitalized COVID-19 patients with completed medical record abstraction and a discharge disposition during the pre-Delta period, the proportion of patients who were admitted to an intensive care unit (ICU), received invasive mechanical ventilation (IMV), or died while hospitalized did not significantly change from the pre-Delta period to the Delta period. The proportion of hospitalized COVID-19 patients who were aged 18-49 years significantly increased, from 24.7% (95% confidence interval [CI] = 23.2%-26.3%) of all hospitalizations in the pre-Delta period, to 35.8% (95% CI = 32.1%-39.5%, p<0.01) during the Delta period. When examined by vaccination status, 71.8% of COVID-19-associated hospitalizations in the Delta period were in unvaccinated adults. Adults aged 18-49 years accounted for 43.6% (95% CI = 39.1%-48.2%) of all hospitalizations among unvaccinated adults during the Delta period. No difference was observed in ICU admission, receipt of IMV, or in-hospital death among nonpregnant hospitalized adults between the pre-Delta and Delta periods. However, the proportion of unvaccinated adults aged 18-49 years hospitalized with COVID-19 has increased as the Delta Variants has become more predominant. Lower vaccination coverage in this age group likely contributed to the increase in hospitalized patients during the Delta period. COVID-19 vaccination is critical for all eligible adults, including those aged <50 years who have relatively low vaccination rates compared with older adults.
• Subjects:
  Adolescent Adult Aged CoronaVirus Infections COVID-19 Female Hospitalization Humans Laboratories Male Middle Aged SARS-CoV-2 Severity Of Illness Index Young Adult

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• Source:
  MMWR Morb Mortal Wkly Rep. 70(43):1513-1519
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/MMWRmm7043e1
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  34710076
• Pubmed Central ID:
  PMC8553023
• Document Type:
  Charts, Diagrams, Etc.
• Genre:
  QuickStats ; Statistics
• Place as Subject:
  United States
• Pages in Document:
  7 pdf pages
• Volume:
  70
• Issue:
  43
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:163e3bf76c9c0ec816b10df59484b5028762ae411477e29405f2219053c7040b0322d70fee7d687c9394ac6f2d0661a6f1a0a7fa602cf637c2798bc1bebfef88
• Download URL:
  https://stacks.cdc.gov/view/cdc/111842/cdc_111842_DS1.pdf
• File Type:
  [PDF - 177.93 KB ]