918. Pilot Surveillance for Carbapenemase Gene-positive Organisms Among Hospitalized Solid Organ Transplant Recipients

Details

• Alternative Title:
  Open Forum Infect Dis
• Personal Author:
  Chan, June L ; Nazarian, Elizabeth ; Musser, Kimberlee A ; Fung, Monica ; Doernberg, Sarah B ; Pouch, Stephanie M ; Pouch, Stephanie M ; Leekha, Surbhi ; Anesi, Judith A ; Kodiyanplakkal, Rosy Priya ; Turbett, Sarah ; Walters, Maroya Spalding ; Epstein, Lauren ; Epstein, Lauren
• Description:
  Background
  
  Carbapenemase gene-positive organisms (CPOs) are associated with infections with high mortality rates and have the potential to facilitate epidemic spread of carbapenem resistance. Passive reporting to CDC identified CPOs among organ transplant recipients, potentially representing an emerging reservoir for spread. We aimed to determine the prevalence of CPOs in hospital units where solid organ transplant (SOT) recipients receive care in order to inform public health action to prevent transmission.
  
  Methods
  
  All healthcare facilities identified one medical unit where SOT recipients received inpatient care and conducted point prevalence surveys (PPS) of all consenting patients on 1-2 designated calendar days. We used the Cepheid Xpert® Carba-R assay to identify carbapenemase genes (blaKPC, blaNDM, blaVIM, blaIMP, blaOXA-48) from rectal swabs; carbapenemase-positive swabs were cultured for organisms. All laboratory testing was conducted at the Wadsworth Center, part of CDC’s Antibiotic Resistance Laboratory Network.
  
  Results
  
  Five participating hospitals performed nine PPS from September 2019 through June 2020. In total, 154 patients were screened and 92 (60%) were SOT recipients (Table). The most common transplanted organs were kidney (44, 48%) and liver (39, 42%). Carbapenemase genes were detected among 5 (5%) SOT recipients, all from a single healthcare facility; 4 (80%) were blaKPC and 1 (20%) was blaNDM. Of the positive specimens cultured, blaKPC was carried by Enterobacter cloacae complex (ECC), Klebsiella pneumoniae, and Klebsiella oxytoca and blaNDM was carried by K. oxytoca; blaKPC was carried by both ECC and K. pneumoniae in a single individual. For SOT patients with CPOs, the median interval from transplantation to swab collection was 108 days (range: 12 to 323). CPOs were only detected in 1 (2%) of 62 non-transplant patients.
  
  Conclusion
  
  Among participating facilities, most did not identify CPOs among patients admitted to transplant units. These findings represent a small number of patients and facilities; additional PPS in areas with varied CPO epidemiology are needed to understand whether SOT recipients should be routinely screened for CPOs.
  
  Disclosures
  
  All Authors: No reported disclosures
  
  
• Subjects:
  AcademicSubjects/MED00290 Poster Abstracts
• Source:
  Open Forum Infect Dis. 2020; 7(Suppl 1):S493-S494
• Pubmed Central ID:
  PMC7776677
• Document Type:
  Journal Article
• Volume:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b5d5b5fc4c9519958878e57bde06257e2229989ca3a36b735b81ae880e85b2a9
• Download URL:
  https://stacks.cdc.gov/view/cdc/111662/cdc_111662_DS1.pdf
• File Type:
  [PDF - 847.91 KB ]