Phylogenomic analysis reveals persistence of gonococcal strains with reduced-susceptibility to extended-spectrum cephalosporins and mosaic penA-34

Details

• Alternative Title:
  Nat Commun
• Personal Author:
  Thomas, Jesse C. ; Joseph, Sandeep J. ; Cartee, John C. ; Pham, Cau D. ; Schmerer, Matthew W. ; Schlanger, Karen ; St. Cyr, Sancta B. ; Kersh, Ellen N. ; Raphael, Brian H.
• Corporate Authors:
  Antimicrobial Resistant Neisseria gonorrhoeae Working Group
• Description:
  The recent emergence of strains of Neisseria gonorrhoeae associated with treatment failures to ceftriaxone, the foundation of current treatment options, has raised concerns over a future of untreatable gonorrhea. Current global data on gonococcal strains suggest that several lineages, predominately characterized by mosaic penA alleles, are associated with elevated minimum inhibitory concentrations (MICs) to extended spectrum cephalosporins (ESCs). Here we report on whole genome sequences of 813 N. gonorrhoeae isolates collected through the Gonococcal Isolate Surveillance Project in the United States. Phylogenomic analysis revealed that one persisting lineage (Clade A, multi-locus sequence type [MLST] ST1901) with mosaic penA-34 alleles, contained the majority of isolates with elevated MICs to ESCs. We provide evidence that an ancestor to the globally circulating MLST ST1901 clones potentially emerged around the early to mid-20th century (1944, credibility intervals [CI]: 1935-1953), predating the introduction of cephalosporins, but coinciding with the use of penicillin. Such results indicate that drugs with novel mechanisms of action are needed as these strains continue to persist and disseminate globally.
• Subjects:
  Alleles Anti-Bacterial Agents Cephalosporin Resistance Cephalosporins Genes, Bacterial Genetic Variation Genome, Bacterial Gonorrhea Humans Microbial Sensitivity Tests Multilocus Sequence Typing Neisseria Gonorrhoeae Phylogeny Recombination, Genetic Sequence Analysis, DNA

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• Source:
  Nat Commun. 12
• Pubmed ID:
  34155204
• Pubmed Central ID:
  PMC8217231
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Volume:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e473a7e4d58f8d9a252309fb1230ac18676c22f7071c1202455b2afdee6ba08f
• Download URL:
  https://stacks.cdc.gov/view/cdc/111612/cdc_111612_DS1.pdf
• File Type:
  [PDF - 1.22 MB ]