Details:

Alternative Title:
MMWR Surveill Summ
Personal Author:
Sunderam, Saswati ; Kissin, Dmitry M. ; Crawford, Sara B. ; Folger, Suzanne G. ; Jamieson, Denise J. ; ... More +
Sunderam, Saswati ; Kissin, Dmitry M. ; Crawford, Sara B. ; Folger, Suzanne G. ; Jamieson, Denise J. ; Warner, Lee ; Barfield, Wanda D. Less -
Corporate Authors:
National Center for Chronic Disease Prevention and Health Promotion (U.S.) ; Div. of Reproductive Health
National Center for Chronic Disease Prevention and Health Promotion (U.S.) ; Div. of Reproductive Health Less -
Description:
Problem/Condition

Since the first U.S. infant conceived with assisted reproductive technology (ART) was born in 1981, both the use of ART and the number of fertility clinics providing ART services have increased steadily in the U.S. ART includes fertility treatments in which eggs or embryos are handled in the laboratory (i.e., in vitro fertilization [IVF] and related procedures). Women who undergo ART procedures are more likely than women who conceive naturally to deliver multiple-birth infants. Multiple births pose substantial risks to both mothers and infants, including obstetric Complications, preterm delivery, and low birthweight infants. This report provides state-specific information for the U.S. (including the District of Columbia and Puerto Rico) on ART procedures performed in 2014 and compares birth outcomes that occurred in 2014 (resulting from ART procedures performed in 2013 and 2014) with outcomes for all infants born in the U.S. in 2014.

Period Covered

2014.

Description of System

In 1996, CDC began collecting data on ART procedures performed in fertility clinics in the U.S. as mandated by the Fertility Clinic Success Rate and Certification Act of 1992 (FCSRCA) (Public Law 102–493). Data are collected through the National ART Surveillance System (NASS), a web-based data collection system developed by CDC. This report includes data from 52 reporting areas (the 50 states, the District of Columbia, and Puerto Rico).

Results

In 2014, a total of 169,568 ART procedures (range: 124 in Wyoming to 21,018 in California) with the intent to transfer at least one embryo were performed in 458 U.S. fertility clinics and reported to CDC. These procedures resulted in 56,028 live-birth deliveries (range: 52 in Wyoming to 7,230 in California) and 68,782 infants born (range: 64 in Wyoming to 8,793 in California). Nationally, the total number of ART procedures performed per million women of reproductive age (15–44 years), a proxy measure of the ART usage rate, was 2,647 (range: 364 in Puerto Rico to 6,726 in Massachusetts). ART use exceeded the national average in 13 reporting areas (Connecticut, Delaware, the District of Columbia, Hawaii, Illinois, Maryland, Massachusetts, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, and Virginia). Eight reporting areas (Connecticut, the District of Columbia, Hawaii, Illinois, Maryland, Massachusetts, New Jersey, and New York) had rates of ART use exceeding 1.5 times the national average.

Interpretation

The percentage of infants conceived with ART varied considerably by reporting area. Multiple births from ART contributed to a substantial proportion of all twins, triplets, and higher-order infants born. Low birthweight and preterm infant birth rates were disproportionately higher among ART-conceived infants than among the overall birth population. Although women aged <35 years are typically considered good candidates for eSET, on average two embryos were transferred per ART procedure with women in this group. Compared with ART-conceived singletons, ART-conceived twins were approximately five times more likely to be born preterm and approximately six times more likely to be born with low birthweight. Singleton infants conceived with ART had higher percentages of preterm birth and low birthweight than all singleton infants born in the U.S. ART use per population unit was geographically variable, with 13 reporting areas showing ART use higher than the national rate. Of the four states (Illinois, Massachusetts, New Jersey, and Rhode Island) with comprehensive statewide-mandated health insurance coverage for ART procedures (i.e., coverage for at least four cycles of IVF), three (Illinois, Massachusetts, and New Jersey) had rates of ART use exceeding 1.5 times the national rate. This type of mandated insurance has been associated with greater use of ART and likely accounts for some of the difference in per capita ART use observed among states.

Public Health Action

Reducing the number of embryos transferred and increasing use of eSET when clinically appropriate could help reduce multiple births and related adverse health consequences. Because twins account for the majority of ART-conceived multiple births, improved provider practices and patient education and counseling on the maternal and infant health risks of having twins are needed. Although ART contributes to high percentages of multiple births, other factors not investigated in this report (e.g., delayed childbearing and use of non-ART fertility treatments) also contribute to multiple births and warrant further study.


Subjects:
[+]
Adolescent Adult Female Humans Infant, Low Birth Weight Infant, Newborn Infant, Premature Population Surveillance Pregnancy Pregnancy, Multiple Pregnancy Outcome Premature Birth Reproductive Techniques, Assisted Surveillance Summaries Young Adult
Source:
MMWR Surveill Summ. 66(6):1-24
Series:
MMWR Survl. Summ.; v. 66, no. 6
Pubmed ID:
28182605
Pubmed Central ID:
PMC5829717
Document Type:
Journal Issue
Place as Subject:
U.S.
Collection(s):
Morbidity and Mortality Weekly Report (MMWR)
Main Document Checksum:
[+]
urn:sha256:affb12cd6761aae9a0f9044bb87b385ffeb947fd71fc41098d470b128a2fae43
Download URL:
https://stacks.cdc.gov/view/cdc/111572/cdc_111572_DS1.pdf
File Type:

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