Unrestrained eating behavior and risk of mortality: a prospective cohort study

Details

• Alternative Title:
  Clin Nutr
• Personal Author:
  Zhang, Yin ; Song, Mingyang ; Yuan, Chen ; Chan, Andrew T. ; Schernhammer, Eva S. ; Wolpin, Brian M. ; Stampfer, Meir J. ; Meyerhardt, Jeffrey A. ; Fuchs, Charles S. ; Roberts, Susan B. ; Rimm, Eric B. ; Willett, Walter C. ; Hu, Frank B. ; Giovannucci, Edward L. ; Ng, Kimmie
• Description:
  Background & Aims
  
  Unrestrained eating behavior has been thought to be a proxy for diet frequency, timing, and caloric intake. We investigated the association of unrestrained eating with mortality risk in the Nurses’ Health Study prospectively.
  
  Methods
  
  During follow-up (1994–2016), 21953 deaths were documented among 63999 eligible participants in analyses of eating anything at any time, 22120 deaths were documented among 65839 participants in analyses of no concern with figure change. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards models.
  
  Results
  
  Eating anything at any time was associated with an increased mortality from cancer (overall HR, 95%CI: 1.07, 1.00–1.13; driven by gastrointestinal tract cancer: 1.30, 1.10–1.54) and respiratory disease (1.16, 1.05–1.29), and decreased cardiovascular disease-specific mortality (0.92, 0.86–0.99), compared to those without this behavior; however, no association was observed between this behavior and all-cause mortality (1.02, 0.99–1.05). Women who reported having no concern with figure change experienced higher risk of mortality from all-cause (1.08, 1.05–1.11), cancer (1.08, 1.02–1.14), and respiratory disease (1.18, 1.08–1.30), compared to those not reporting this behavior. Their combined effect was associated with a higher all-cause (1.09, 1.04–1.14), cancer-specific (overall: 1.18, 1.09–1.28; gastrointestinal tract cancer: 1.36, 1.08–1.71; lung cancer: 1.09; 1.04–1.14), and respiratory disease-specific (1.30, 1.13–1.50) mortality, and was inversely associated with cardiovascular disease-specific mortality (0.88, 0.80–0.98), compared to those exhibiting the opposite.
  
  Conclusions
  
  Unrestrained eating was associated with increased risk of all-cause, cancer-specific (particularly for gastrointestinal tract cancer and lung cancer), and respiratory disease-specific mortality, and decreased risk of cardiovascular disease-specific mortality.
  
  
• Subjects:
  Adult Aged Cardiovascular Diseases Cause Of Death Diet Feeding Behavior Female Follow-Up Studies Humans Middle Aged Neoplasms Proportional Hazards Models Prospective Studies Respiratory Tract Diseases Risk Factors

  More +
• Keywords:
  All-cause Mortality Buprenorphine Cause-specific Mortality Methadone Mortality Naltrexone Treatment Unrestrained Eating Behavior
• Source:
  Clin Nutr. 40(11):5419-5429
• Pubmed ID:
  34653818
• Pubmed Central ID:
  PMC8571025
• Document Type:
  Journal Article
• Funding:
  U01 CA210171/CA/NCI NIH HHSUnited States/ ; R01 CA137178/CA/NCI NIH HHSUnited States/ ; R01 CA205406/CA/NCI NIH HHSUnited States/ ; UM1 CA186107/CA/NCI NIH HHSUnited States/ ; R00 CA215314/CA/NCI NIH HHSUnited States/ ; R35 CA253185/CA/NCI NIH HHSUnited States/ ; P50 CA127003/CA/NCI NIH HHSUnited States/ ; R01 OH009803/OH/NIOSH CDC HHSUnited States/ ; P01 CA087969/CA/NCI NIH HHSUnited States/
• Volume:
  40
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:201c323ff953f96935c27069269ecd80f7585f980db41716422328b7274b610bcb68c918b8f052af1e937319e09b56fe0443bcc0a58b5307432115ff7e2da06c
• Download URL:
  https://stacks.cdc.gov/view/cdc/111344/cdc_111344_DS1.pdf
• File Type:
  [PDF - 185.38 KB ]