Unrestrained eating behavior and risk of mortality: a prospective cohort study

Zhang, Yin; Song, Mingyang; Yuan, Chen; Chan, Andrew T.; Schernhammer, Eva S.; Wolpin, Brian M.; Stampfer, Meir J.; Meyerhardt, Jeffrey A.; Fuchs, Charles S.; Roberts, Susan B.; Rimm, Eric B.; Willett, Walter C.; Hu, Frank B.; Giovannucci, Edward L.; Ng, Kimmie

doi:10.1016/j.clnu.2021.09.014

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Unrestrained eating behavior and risk of mortality: a prospective cohort study

11 2021
By Zhang, Yin ; Song, Mingyang ; Yuan, Chen ; ...
http://dx.doi.org/10.1016/j.clnu.2021.09.014
Source: Clin Nutr. 40(11):5419-5429

[PDF-185.38 KB]

English

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Details:

Alternative Title:

Clin Nutr
Personal Author:

Zhang, Yin ; Song, Mingyang ; Yuan, Chen ; Chan, Andrew T. ; Schernhammer, Eva S. ; ... More +

Zhang, Yin ; Song, Mingyang ; Yuan, Chen ; Chan, Andrew T. ; Schernhammer, Eva S. ; Wolpin, Brian M. ; Stampfer, Meir J. ; Meyerhardt, Jeffrey A. ; Fuchs, Charles S. ; Roberts, Susan B. ; Rimm, Eric B. ; Willett, Walter C. ; Hu, Frank B. ; Giovannucci, Edward L. ; Ng, Kimmie Less -
Description:

Background & Aims

Unrestrained eating behavior has been thought to be a proxy for diet frequency, timing, and caloric intake. We investigated the association of unrestrained eating with mortality risk in the Nurses’ Health Study prospectively.

Methods

During follow-up (1994–2016), 21953 deaths were documented among 63999 eligible participants in analyses of eating anything at any time, 22120 deaths were documented among 65839 participants in analyses of no concern with figure change. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards models.

Results

Eating anything at any time was associated with an increased mortality from cancer (overall HR, 95%CI: 1.07, 1.00–1.13; driven by gastrointestinal tract cancer: 1.30, 1.10–1.54) and respiratory disease (1.16, 1.05–1.29), and decreased cardiovascular disease-specific mortality (0.92, 0.86–0.99), compared to those without this behavior; however, no association was observed between this behavior and all-cause mortality (1.02, 0.99–1.05). Women who reported having no concern with figure change experienced higher risk of mortality from all-cause (1.08, 1.05–1.11), cancer (1.08, 1.02–1.14), and respiratory disease (1.18, 1.08–1.30), compared to those not reporting this behavior. Their combined effect was associated with a higher all-cause (1.09, 1.04–1.14), cancer-specific (overall: 1.18, 1.09–1.28; gastrointestinal tract cancer: 1.36, 1.08–1.71; lung cancer: 1.09; 1.04–1.14), and respiratory disease-specific (1.30, 1.13–1.50) mortality, and was inversely associated with cardiovascular disease-specific mortality (0.88, 0.80–0.98), compared to those exhibiting the opposite.

Conclusions

Unrestrained eating was associated with increased risk of all-cause, cancer-specific (particularly for gastrointestinal tract cancer and lung cancer), and respiratory disease-specific mortality, and decreased risk of cardiovascular disease-specific mortality.
Keywords:

[+]

Adult Aged All-cause Mortality Cardiovascular Diseases Cause-specific Mortality Cause Of Death Diet Feeding Behavior Female Follow-Up Studies Humans Male Middle Aged Neoplasms Proportional Hazards Models Prospective Studies Respiratory Tract Diseases Risk Factors Unrestrained Eating Behavior
Source:

Clin Nutr. 40(11):5419-5429
Pubmed ID:

34653818
Pubmed Central ID:

PMC8571025
Document Type:

Journal Article
Funding:

U01 CA210171/CA/NCI NIH HHSUnited States/ ; R01 CA137178/CA/NCI NIH HHSUnited States/ ; R01 CA205406/CA/NCI NIH HHSUnited States/ ; UM1 CA186107/CA/NCI NIH HHSUnited States/ ; R33 CA160344/CA/NCI NIH HHSUnited States/ ; ... More +

U01 CA210171/CA/NCI NIH HHSUnited States/ ; R01 CA137178/CA/NCI NIH HHSUnited States/ ; R01 CA205406/CA/NCI NIH HHSUnited States/ ; UM1 CA186107/CA/NCI NIH HHSUnited States/ ; R33 CA160344/CA/NCI NIH HHSUnited States/ ; R00 CA215314/CA/NCI NIH HHSUnited States/ ; R35 CA253185/CA/NCI NIH HHSUnited States/ ; P50 CA127003/CA/NCI NIH HHSUnited States/ ; R01 OH009803/OH/NIOSH CDC HHSUnited States/ ; P01 CA087969/CA/NCI NIH HHSUnited States/ Less -
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:9e869869775f28980ac4c074ad98c8181baa79072f40c75742ba318c5aecc722
Download URL:

https://stacks.cdc.gov/view/cdc/111344/cdc_111344_DS1.pdf
File Type:

	nihms-1741204.nxml	xml
	NIHMS1741204-supplement-1.docx	docx

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