Details:

Alternative Title:
Curr Opin Nephrol Hypertens
Publisher's site:
http://dx.doi.org/10.1097/MNH.0000000000000735
Personal Author:
Zabetian, Azadeh ; Coca, Steven
Zabetian, Azadeh ; Coca, Steven Less -
Description:
PURPOSE OF REVIEW

Chronic kidney disease (CKD) is a silent disease, causing significant health and economic burden worldwide. It is of strong clinical value to identify novel prognostic, predictive, and pharmacodynamic biomarkers of kidney function as current available measures have limitations. We reviewed the advances in biomarkers in CKD over the preceding year.

RECENT FINDINGS

The most frequently studied prognostic plasma biomarkers during recent year were plasma TNFR1, TNFR2, KIM1, and urinary MCP-1 and EGF. New biomarkers such as plasma WFDC2, MMP-7, EFNA4, EPHA2 may also have potential to serve as prognostic biomarkers. There is a shortage of data on biomarkers that are predictive of response to treatments. Data on novel biomarkers to serve as pharmacodynamic biomarkers are limited, but there is emerging data that plasmaTNFR1, TNFR2, KIM-1 are not only prognostic at baseline, but can contribute to time-updated response signals in response to therapy.

SUMMARY

Data continue to emerge on applicable biomarkers for prognostic clinical risk stratification, prediction of therapeutic response, and assessment of early efficacy of interventions. While more studies are needed for refinement and specific clinical utility, there seems to be sufficient data to support clinical implementation for some biomarkers.


Subject:
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Article Biomarkers Chronic Kidney Disease Humans Prediction Prognosis Renal Insufficiency, Chronic WAP Four-Disulfide Core Domain Protein 2 Biomarkers Prognosis
Source:
Curr Opin Nephrol Hypertens. 30(6):531-537
Pubmed ID:
34475336
Pubmed Central ID:
PMC8490303
Document Type:
Journal Article
Funding:
R01 DK096549/DK/NIDDK NIH HHSUnited States/ ; R01 DK115562/DK/NIDDK NIH HHSUnited States/ ; U01 DK106962/DK/NIDDK NIH HHSUnited States/ ; R01 HL085757/HL/NHLBI NIH HHSUnited States/ ; R01 DK112258/DK/NIDDK NIH HHSUnited States/ ; ... More +
R01 DK096549/DK/NIDDK NIH HHSUnited States/ ; R01 DK115562/DK/NIDDK NIH HHSUnited States/ ; U01 DK106962/DK/NIDDK NIH HHSUnited States/ ; R01 HL085757/HL/NHLBI NIH HHSUnited States/ ; R01 DK112258/DK/NIDDK NIH HHSUnited States/ ; U01 OH011326/OH/NIOSH CDC HHSUnited States/ ; R01 DK126477/DK/NIDDK NIH HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:9a597b05f3dd4fc25ff99ad423f55011cd281a2c766927d523788028d72f3cab
Download URL:
https://stacks.cdc.gov/view/cdc/111318/cdc_111318_DS1.pdf
File Type:

Supporting Files

• nihms-1732759.nxml

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