A population-based study of invitation to and participation in clinical trials among women with early-stage breast cancer

Details

• Alternative Title:
  Breast Cancer Res Treat
• Personal Author:
  Patel, Monica A. ; Shah, Jennifer L. ; Abrahamse, Paul H. ; Jagsi, Reshma ; Katz, Steven J. ; Hawley, Sarah T. ; Veenstra, Christine M.
• Description:
  Purpose ; Although many studies clearly demonstrate disparities in cancer clinical trial enrollment, there is a lack of consensus on potential causes. Furthermore, virtually nothing is known about associations between patients’ decision-making style and their participation in clinical trials. ; Methods ; Women with newly diagnosed, stage 0-II breast cancer reported to the Georgia and Los Angeles County Surveillance, Epidemiology, and End Results (SEER) registries in 2013–14 were surveyed approximately seven months after diagnosis. We investigated two primary outcome variables: 1) invitation to participate in a clinical trial, 2) participation in a clinical trial. We evaluated bivariate associations using chi-squared tests and used multivariable logistic regression models to investigate associations between patient variables, including decision-making style, and the primary outcomes. ; Results ; 2578 patients responded (71% response rate); 30% were > age 65, 18% were black, 18% were Latina, 29% had ≤ high school education. 10% of patients reported invitation to participate in a clinical trial; 5% reported participation in a clinical trial. After adjustment younger age, receipt of chemotherapy or radiation, disease stage, and a more rational (versus more intuitive) decision-making style were associated with a higher odds of invitation to participate. Being married was associated with a higher odds of participation; having an annual family income ≥ $40,000 was associated with a lower odds of participation. ; Conclusions ; 10% of patients reported invitation to participate in a clinical trial, and half of these reported participation. Invitation to participate varied by age and decision-making style, and participation varied by marital status and income.
• Subjects:
  • Adult
  • Black or African American
  • Aged
  • Aged, 80 and over
  • Breast Neoplasms
  • Female
  • Georgia
  • Hispanic or Latino
  • Humans
  • Middle Aged
  More +
• Keywords:
  • Breast cancer
  • clinical trial
  • participation
  • enrollment
  • disparities
  • Naltrexone
  • Buprenorphine
  • Methadone
  • Mortality
  • Treatment
• Source:
  Breast Cancer Res Treat. 184(2):507-518
• Pubmed ID:
  32757135
• Pubmed Central ID:
  PMC7606336
• Document Type:
  Journal Article
• Funding:
  HHSN261201000140C/CA/NCI NIH HHSUnited States/ ; HHSN261201000035C/CA/NCI NIH HHSUnited States/ ; HHSN261201000035I/CA/NCI NIH HHSUnited States/ ; HHSN261201300015C/CA/NCI NIH HHSUnited States/ ; HHSN261201000034C/CA/NCI NIH HHSUnited States/ ; T32 CA009357/CA/NCI NIH HHSUnited States/ ; U58 DP003862/DP/NCCDPHP CDC HHSUnited States/ ; K07 CA196752/CA/NCI NIH HHSUnited States/ ; P01 CA163233/CA/NCI NIH HHSUnited States/ ; U58 DP003875/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  184
• Issue:
  2
• Download URL:
  https://stacks.cdc.gov/view/cdc/111123/cdc_111123_DS1.pdf
• File Type:
  [PDF - 467.14 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:5ae2c798b88bb18afedb375d6d9fb99d90d4c3d8a730b3b1af94b8924c5924f8bea59a6ace6d59a7fcb4c4a7fcf73fe057bf285d2ef25141275ae2d1a7b459da