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Maternal gestational diabetes and childhood hyperlipidemia
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11 2021
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Source: Diabet Med. 38(11):e14606
[PDF-328.89 KB]
Details:
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Alternative Title:Diabet Med
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Personal Author:
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Description:Aims:
To assess dyslipidemia risk between children exposed to maternal gestational diabetes mellitus (GDM) and those not exposed.
Methods:
We recruited 1144 mother-child pairs (572 GDM and 572 non-GDM women matched by their offspring’s age and sex). The age of offspring ranged from 3 to 9 years old. We used general linear models to compare mean values of different lipid profiles among children born to mothers with and without GDM. Logistic regression models were used to assess associations of maternal GDM with abnormal lipid profiles in offspring.
Results:
After adjustment for maternal and children’s characteristics, children born to mothers with GDM had lower mean values of high-density-lipoprotein (HDL) cholesterol (1.40±0.01 vs 1.50±0.01; P <0.001) and higher mean levels of triglycerides/HDL cholesterol ratio (0.37±0.01 vs 0.35±0.01; P <0.05) in comparison with their counterparts born to mothers without GDM. Multivariate-adjusted odds ratios among children exposed to mothers with GDM compared with the counterparts were 2.11 (95% confidence interval [CI 1.15–3.88]) for low HDL cholesterol and 1.35 (95% CI 1.00–1.81) for high triglycerides/HDL cholesterol ratio, respectively.
Conclusions:
Maternal GDM was associated with an increased risk of hyperlipidemia in the offspring during early childhood aged from 3 to 9 years old.
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Subjects:
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Source:
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Pubmed ID:34021927
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Pubmed Central ID:PMC8511106
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Document Type:
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Funding:2020FYH020/National Center for Women's and Children's Health, China CDC/ ; U54 GM104940/GM/NIGMS NIH HHSUnited States/ ; R01DK100790/DK/NIDDK NIH HHSUnited States/ ; U54GM104940/GM/NIGMS NIH HHSUnited States/ ; European Foundation for the Study of Diabetes/Chinese Diabetes Society/Lilly program/ ; ... More +
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Volume:38
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Issue:11
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