Temporal Association of Prostate Cancer Incidence with World Trade Center Rescue/Recovery Work

Details

• Alternative Title:
  Occup Environ Med
• Personal Author:
  Goldfarb, David G. ; Zeig-Owens, Rachel ; Kristjansson, Dana ; Li, Jiehui ; Brackbill, Robert M. ; Farfel, Mark R. ; Cone, James E. ; Yung, Janette ; Kahn, Amy R. ; Qiao, Baozhen ; Schymura, Maria J. ; Webber, Mayris P. ; Dasaro, Christopher R. ; Shapiro, Moshe ; Lucchini, Roberto G. ; Todd, Andrew C. ; Prezant, David J. ; Boffetta, Paolo ; Hall, Charles B.
• Description:
  Background:
  
  The World Trade Center (WTC) attacks on 9/11/2001 created a hazardous environment with known and suspected carcinogens. Previous studies have identified an increased risk of prostate cancer in responder cohorts compared to the general male population.
  
  Objectives:
  
  To estimate the length of time to prostate cancer among WTC rescue/recovery workers by determining specific time periods during which the risk was significantly elevated.
  
  Methods:
  
  Person-time accruals began six months after enrollment into a WTC cohort and ended at death or 12/31/2015. Cancer data were obtained through linkages with 13 state cancer registries. New York State was the comparison population. We used Poisson regression to estimate hazard ratios and 95% confidence intervals; change points in rate ratios were estimated using profile likelihood.
  
  Results:
  
  The analytic cohort included 54,394 male rescue/recovery workers. We observed 1,120 incident prostate cancer cases. During 2002–2006, no association with WTC exposure was detected. Beginning in 2007, a 24% increased risk (HR: 1.24, 95%CI: 1.16–1.32) was observed among WTC rescue/recovery workers when compared with New York State. Comparing those who arrived earliest at the disaster site on the morning of 9/11/2001 or any time on 9/12/2001 to those who first arrived later, we observed a positive, monotonic, dose-response association in the early (2002–2006) and late (2007–2015) periods.
  
  Conclusions:
  
  Risk of prostate cancer was significantly elevated beginning in 2007 in the WTC Combined Rescue/Recovery Cohort. While unique exposures at the disaster site might have contributed to the observed effect, screening practices including routine prostate specific antigen screening cannot be discounted.
  
  
• Subjects:
  Adult Emergency Responders Humans Incidence Male Models, Statistical New York City Occupational Exposure Prostatic Neoplasms Risk Factors September 11 Terrorist Attacks Time Factors Young Adult

  More +
• Source:
  Occup Environ Med. 78(10):699-706
• Pubmed ID:
  34507966
• Pubmed Central ID:
  PMC8458078
• Document Type:
  Journal Article
• Funding:
  HHSN261201800032C/CA/NCI NIH HHSUnited States/ ; HHSN261201800009C/CA/NCI NIH HHSUnited States/ ; U01 OH011931/OH/NIOSH CDC HHSUnited States/ ; HHSN261201800015I/CA/NCI NIH HHSUnited States/ ; U01 OH011932/OH/NIOSH CDC HHSUnited States/ ; U50 TS272750/TS/ATSDR CDC HHSUnited States/ ; HHSN261201800032I/CA/NCI NIH HHSUnited States/ ; U50 OH009739/OH/NIOSH CDC HHSUnited States/ ; HHSN261201800015C/CA/NCI NIH HHSUnited States/ ; P30 CA013330/CA/NCI NIH HHSUnited States/ ; U01 OH011681/OH/NIOSH CDC HHSUnited States/ ; NU58DP006344/DP/NCCDPHP CDC HHSUnited States/ ; U01 OH011480/OH/NIOSH CDC HHSUnited States/ ; HHSN261201800009I/CA/NCI NIH HHSUnited States/ ; U01 OH011315/OH/NIOSH CDC HHSUnited States/
• Volume:
  78
• Issue:
  10
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:500220b73dc538a33b083e332fc57d6589b04c17358e9d456cd2c6c137b6ff9eaa21fb55a5102427a883509243de65e0ca25350ac05de20d4f731d58f0ee6795
• Download URL:
  https://stacks.cdc.gov/view/cdc/110313/cdc_110313_DS1.pdf
• File Type:
  [PDF - 735.35 KB ]