Hepatitis B prevalence association with sexually transmitted infections: A systematic review and meta-analysis

Details

• Alternative Title:
  Sex Health
• Personal Author:
  Marseille, Elliot ; Harris, Aaron M. ; Horvath, Hacsi ; Parriott, Andrea ; Malekinejad, Mohsen ; Nelson, Noele P. ; Van Handel, Michelle ; Kahn, James G.
• Description:
  Background.
  
  Hepatitis B vaccination is recommended for persons with current or past sexually transmitted infections (STI). Our aim is to systematically assess the association of hepatitis B virus (HBV) sero-markers for current or past infection with syphilis, chlamydia, gonorrhea, or unspecified STIs.
  
  Methods.
  
  We conducted a systematic review and meta-analysis. PubMed, Embase, and Web of Science from 1982 –2018 were searched using MeSH terms for HBV, STIs and epidemiology. We included studies conducted in Organization for Economic Cooperation and Development countries or Latin America that permit the calculation of prevalence ratios (PRs) for HBV and STIs and extracted PRs and counts by HBV and STI status.
  
  Results.
  
  Of 3,144 identified studies, 43 met inclusion requirements, yielding 72 PRs. We stratified outcomes by HBV sero-markers (surface antigen [HBsAg], core antigen [anti-HBc], combined ), STI pathogen (syphilis, gonorrhea/chlamydia, unspecified), and STI history (current, past) resulting in 18 potential outcome groups, for which results were available for 14. For the four outcome groups related to HBsAg, PR point estimates ranged from 1.65 – 6.76. For the five outcome groups related to anti-HBc, PRs ranged from 1.30 – 1.82; and for the five outcome groups related to combined HBV markers, PRs ranged from 1.15 – 1.89). The median HBsAg prevalence among people with a current or past STI was 4.17; not all studies reported HBsAg. Study settings and populations varied.
  
  Conclusion.
  
  This review found evidence of association between HBV infection and current or past STIs.
  
  
• Subjects:
  Article Chlamydia Gonorrhea Hepatitis B Meta-analysis Sexually Transmitted Infections Syphilis Systematic Review
• Source:
  Sex Health. 18(3):269-279
• Pubmed ID:
  34183114
• Pubmed Central ID:
  PMC8457403
• Document Type:
  Journal Article
• Funding:
  R37 DA015612/DA/NIDA NIH HHSUnited States/ ; U38 PS004649/PS/NCHHSTP CDC HHSUnited States/
• Volume:
  18
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b5852f27b77e8a402f7aab82a2462e2feaf8e3400081d82ec735db55fc56e53f
• Download URL:
  https://stacks.cdc.gov/view/cdc/110305/cdc_110305_DS1.pdf
• File Type:
  [PDF - 450.08 KB ]