Effectiveness of COVID-19 mRNA Vaccines Against COVID-19–Associated Hospitalization — Five Veterans Affairs Medical Centers, U.S. February 1–August 6, 2021

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Bajema, Kristina L. ; Dahl, Rebecca M. ; Prill, Mila M. ; Meites, Elissa ; Rodriguez-Barradas, Maria C. ; Marconi, Vincent C. ; Beenhouwer, David O. ; Brown, Sheldon T. ; Holodniy, Mark ; Lucero-Obusan, Cynthia ; Rivera-Dominguez, Gilberto ; Morones, Rosalba Gomez ; Whitmire, Alexis ; Goldin, Evan B. ; Evener, Steve L. ; Tremarelli, Maraia ; Tong, Suxiang ; Hall, Aron J. ; Schrag, Stephanie J. ; McMorrow, Meredith ; Kobayashi, Miwako ; Verani, Jennifer R. ; Surie, Diya ; Ahmadi-Izadi, Ghazal ; Burnette, Joy ; Deovic, Rijalda ; Epstein, Lauren ; Hartley, Amy ; Morales, Elena ; Tanner, Tehquin ; Patel, Nina ; Tunson, Ashley ; Elliot, Katherine ; Graham, Ilda ; Lama, Diki ; Pena, Ismael ; Perea, Adrienne ; Perez, Guerry Anabelle ; Simelane, Johane ; Smith, Sarah ; Tallin, Gabriela ; Tisi, Amelia ; Lopez, Alonso Arellano ; Gonzalez, Miguel Covarrubias ; Lengi, Bashir ; Mansouri, Dena ; Tamez, Mariana Vanoye ; Aryanfar, Babak ; Lee-Chang, Ian ; Jeong, Chan ; Matolek, Anthony ; Mendoza, Chad ; Poteshkina, Aleksandra ; Naeem, Saadia ; Agrawal, Madhuri ; Lopez, Jessica ; Peters, Theresa ; Kudryavtseva, Geliya ; Cates, Jordan ; Folster, Jennifer M. ; Kambhampati, Anita ; Kelleher, Anna ; Li, Yan ; Ng, Han Jia ; Tao, Ying
• Corporate Authors:
  SUPERNOVA COVID-19 Surveillance Group ; Surveillance Platform for Enteric and Respiratory Infectious Organisms at the VA (SUPERNOVA) ; COVID-19 Surveillance Group
• Description:
  COVID-19 mRNA vaccines (Pfizer-BioNTech and Moderna) have been shown to be highly protective against COVID-19-associated hospitalizations (1-3). Data are limited on the level of protection against hospitalization among disproportionately affected populations in the U.S. particularly during periods in which the B.1.617.2 (Delta) Variants of SARS-CoV-2, the Virus that causes COVID-19, predominates (2). U.S. veterans are older, more racially diverse, and have higher prevalences of underlying medical conditions than persons in the general U.S. population (2,4). CDC assessed the effectiveness of mRNA vaccines against COVID-19-associated hospitalization among 1,175 U.S. veterans aged ≥18 years hospitalized at five Veterans Affairs Medical Centers (VAMCs) during February 1-August 6, 2021. Among these hospitalized persons, 1,093 (93.0%) were men, the median age was 68 years, 574 (48.9%) were non-Hispanic Black (Black), 475 were non-Hispanic White (White), and 522 (44.4%) had a Charlson comorbidity index score of ≥3 (5). Overall adjusted vaccine effectiveness against COVID-19-associated hospitalization was 86.8% (95% confidence interval [CI] = 80.4%-91.1%) and was similar before (February 1-June 30) and during (July 1-August 6) SARS-CoV-2 Delta Variants predominance (84.1% versus 89.3%, respectively). Vaccine effectiveness was 79.8% (95% CI = 67.7%-87.4%) among adults aged ≥65 years and 95.1% (95% CI = 89.1%-97.8%) among those aged 18-64 years. COVID-19 mRNA vaccines are highly effective in preventing COVID-19-associated hospitalization in this older, racially diverse population of predominately male U.S. veterans. Additional evaluations of vaccine effectiveness among various age groups are warranted. To prevent COVID-19-related hospitalizations, all eligible persons should receive COVID-19 vaccination.
• Subjects:
  Adolescent Adult Aged CoronaVirus Infections COVID-19 COVID-19 Vaccines Female Hospitalization Hospitals, Veterans Humans Male Middle Aged Vaccines, Synthetic Veterans Young Adult

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• Source:
  MMWR Morbidity Mortal Weekly Rep. 70(37):1294-1299
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/MMWRmm7037e3
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  34529636
• Pubmed Central ID:
  PMC8445376
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  6 pdf pages
• Volume:
  70
• Issue:
  37
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:ae38871e9f84c0dd6bb53ed0e46e9283339b4580aed46968c0278ce6ea4117d645033bf0179875b34fc688ee0a6a1b3bd0eb82a2fc9034a7f44e7d49d8bb4269
• Download URL:
  https://stacks.cdc.gov/view/cdc/110255/cdc_110255_DS1.pdf
• File Type:
  [PDF - 364.31 KB ]