Monitoring Incidence of COVID-19 Cases, Hospitalizations, and Deaths, by Vaccination Status — 13 U.S. Jurisdictions, April 4–July 17, 2021

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Scobie, Heather M. ; Johnson, Amelia G. ; Suthar, Amitabh B. ; Severson, Rachel ; Alden, Nisha B. ; Balter, Sharon ; Bertolino, Daniel ; Blythe, David ; Brady, Shane ; Cadwell, Betsy ; Cheng, Iris ; Davidson, Sherri ; Delgadillo, Janelle ; Devinney, Katelynn ; Duchin, Jeff ; Duwell, Monique ; Fisher, Rebecca ; Fleischauer, Aaron ; Grant, Ashley ; Griffin, Jennifer ; Haddix, Meredith ; Hand, Julie ; Hanson, Matt ; Hawkins, Eric ; Herlihy, Rachel K. ; Hicks, Liam ; Holtzman, Corinne ; Hoskins, Mikhail ; Hyun, Judie ; Kaur, Ramandeep ; Kay, Meagan ; Kidrowski, Holly ; Kim, Curi ; Komatsu, Kenneth ; Kugeler, Kiersten ; Lewis, Melissa ; Lyons, B. Casey ; Lyons, Shelby ; Lynfield, Ruth ; McCaffrey, Keegan ; McMullen, Chelsea ; Milroy, Lauren ; Meyer, Stephanie ; Nolen, Leisha ; Patel, Monita R. ; Pogosjans, Sargis ; Reese, Heather E. ; Saupe, Amy ; Sell, Jessica ; Sokol, Theresa ; Sosin, Daniel ; Stanislawski, Emma ; Stevens, Kelly ; Vest, Hailey ; White, Kelly ; Wilson, Erica ; MacNeil, Adam ; Ritchey, Matthew D. ; Silk, Benjamin J.
• Description:
  COVID-19 vaccine breakthrough infection Surveillance helps monitor Trends in disease incidence and severe outcomes in fully vaccinated persons, including the impact of the highly transmissible B.1.617.2 (Delta) Variants of SARS-CoV-2, the Virus that causes COVID-19. Reported COVID-19 cases, hospitalizations, and deaths occurring among persons aged ≥18 years during April 4-July 17, 2021, were analyzed by vaccination status across 13 U.S. jurisdictions that routinely linked case Surveillance and immunization registry data. Averaged weekly, age-standardized incidence rate ratios (IRRs) for cases among persons who were not fully vaccinated compared with those among fully vaccinated persons decreased from 11.1 (95% confidence interval [CI] = 7.8-15.8) to 4.6 (95% CI = 2.5-8.5) between two periods when prevalence of the Delta Variants was lower (<50% of sequenced isolates; April 4-June 19) and higher (≥50%; June 20-July 17), and IRRs for hospitalizations and deaths decreased between the same two periods, from 13.3 (95% CI = 11.3-15.6) to 10.4 (95% CI = 8.1-13.3) and from 16.6 (95% CI = 13.5-20.4) to 11.3 (95% CI = 9.1-13.9). Findings were consistent with a potential decline in vaccine protection against confirmed SARS-CoV-2 infection and continued strong protection against COVID-19-associated hospitalization and death. Getting vaccinated protects against severe illness from COVID-19, including the Delta Variants, and monitoring COVID-19 incidence by vaccination status might provide early signals of changes in vaccine-related protection that can be confirmed through well-controlled vaccine effectiveness (VE) studies.
• Subjects:
  Adolescent Adult Aged CoronaVirus Infections COVID-19 COVID-19 Vaccines Hospitalization Humans Incidence Middle Aged Vaccination Young Adult

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• Source:
  MMWR Morbidity Mortal Weekly Rep. 70(37):1284-1290
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/MMWRmm7037e1
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  34529637
• Pubmed Central ID:
  PMC8445374
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  7 pdf pages
• Volume:
  70
• Issue:
  37
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:a19ee927df70b1f9c4f0cd85dc750196fd8dc5917fa47ed813abe3e184ad62d666a3e73f56cba0face59e0610db1e84c76cf8b30c1cbf937f675ec84cb1bb726
• Download URL:
  https://stacks.cdc.gov/view/cdc/110253/cdc_110253_DS1.pdf
• File Type:
  [PDF - 484.06 KB ]