Association Between COVID-19 and Myocarditis Using Hospital-Based Administrative Data — U.S. March 2020–January 2021

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Boehmer, Tegan K. ; Kompaniyets, Lyudmyla ; Lavery, Amy M. ; Hsu, Joy ; Ko, Jean Y. ; Yusuf, Hussain ; Romano, Sebastian D. ; Gundlapalli, Adi V. ; Oster, Matthew E. ; Harris, Aaron M.
• Description:
  Viral infections are a common cause of myocarditis, an inflammation of the heart muscle (myocardium) that can result in hospitalization, heart failure, and sudden death (1). Emerging data suggest an association between COVID-19 and myocarditis (2-5). CDC assessed this association using a large, U.S. hospital-based administrative database of health care encounters from >900 hospitals. Myocarditis inpatient encounters were 42.3% higher in 2020 than in 2019. During March 2020-January 2021, the period that coincided with the COVID-19 pandemic, the risk for myocarditis was 0.146% among patients diagnosed with COVID-19 during an inpatient or hospital-based outpatient encounter and 0.009% among patients who were not diagnosed with COVID-19. After adjusting for patient and hospital characteristics, patients with COVID-19 during March 2020-January 2021 had, on average, 15.7 times the risk for myocarditis compared with those without COVID-19 (95% confidence interval [CI] = 14.1-17.2); by age, risk ratios ranged from approximately 7.0 for patients aged 16-39 years to >30.0 for patients aged <16 years or ≥75 years. Overall, myocarditis was uncommon among persons with and without COVID-19; however, COVID-19 was significantly associated with an increased risk for myocarditis, with risk varying by age group. These findings underscore the importance of implementing evidence-based COVID-19 Prevention strategies, including vaccination, to reduce the public health impact of COVID-19 and its associated Complications.
• Subjects:
  Adolescent Adult Aged CoronaVirus Infections COVID-19 Databases, Factual Female Humans Male Medical Records Middle Aged Myocarditis Risk Assessment Risk Factors Young Adult

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• Source:
  MMWR Morbidity Mortal Weekly Rep. 70(35):1228-1232
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/MMWRmm7035e5
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  34473684
• Pubmed Central ID:
  PMC8422872
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  5 pdf pages
• Volume:
  70
• Issue:
  35
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:487921da08be4db2b7ae0ed5eeb0fc962d9591d8030457cea6b5582989c1796b6aced9e938946bd98dbb04269eec1d3cb7ab7508ce98362e9abbbaf574f3a2aa
• Download URL:
  https://stacks.cdc.gov/view/cdc/110237/cdc_110237_DS1.pdf
• File Type:
  [PDF - 157.80 KB ]