Sustained Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Associated Hospitalizations Among Adults — United States, March–July 2021

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Tenforde, Mark W. ; Self, Wesley H. ; Naioti, Eric A. ; Ginde, Adit A. ; Douin, David J. ; Olson, Samantha M. ; Talbot, H. Keipp ; Casey, Jonathan D. ; Mohr, Nicholas M. ; Zepeski, Anne ; Gaglani, Manjusha ; McNeal, Tresa ; Ghamande, Shekhar ; Shapiro, Nathan I. ; Gibbs, Kevin W. ; Files, D. Clark ; Hager, David N. ; Shehu, Arber ; Prekker, Matthew E. ; Erickson, Heidi L. ; Gong, Michelle N. ; Mohamed, Amira ; Henning, Daniel J. ; Steingrub, Jay S. ; Peltan, Ithan D. ; Brown, Samuel M. ; Martin, Emily T. ; Monto, Arnold S. ; Khan, Akram ; Hough, Catherine L. ; Busse, Laurence W. ; ten Lohuis, Caitlin C. ; Duggal, Abhijit ; Wilson, Jennifer G. ; Gordon, Alexandra June ; Qadir, Nida ; Chang, Steven Y. ; Mallow, Christopher ; Rivas, Carolina ; Babcock, Hilary M. ; Kwon, Jennie H. ; Exline, Matthew C. ; Halasa, Natasha ; Chappell, James D. ; Lauring, Adam S. ; Grijalva, Carlos G. ; Rice, Todd W. ; Jones, Ian D. ; Stubblefield, William B. ; Baughman, Adrienne ; Womack, Kelsey N. ; Lindsell, Christopher J. ; Hart, Kimberly W. ; Zhu, Yuwei ; Stephenson, Meagan ; Schrag, Stephanie J. ; Kobayashi, Miwako ; Verani, Jennifer R. ; Patel, Manish M. ; Calhoun, Nicole ; Murthy, Kempapura ; Herrick, Judy ; McKillop, Amanda ; Hoffman, Eric ; Zayed, Martha ; Smith, Michael ; Settele, Natalie ; Ettlinger, Jason ; Priest, Elisa ; Thomas, Jennifer ; Arroliga, Alejandro ; Beeram, Madhava ; Kindle, Ryan ; Kozikowski, Lori-Ann ; De Souza, Lesley ; Ouellette, Scott ; Thornton-Thompson, Sherell ; Tyler, Patrick ; Mehkri, Omar ; Ashok, Kiran ; Gole, Susan ; King, Alexander ; Poynter, Bryan ; Stanley, Nicholas ; Hendrickson, Audrey ; Maruggi, Ellen ; Scharber, Tyler ; Jorgensen, Jeffrey ; Bowers, Robert ; King, Jennifer ; Aston, Valerie ; Armbruster, Brent ; Rothman, Richard E. ; Nair, Rahul ; Chen, Jen-Ting (Tina) ; Karow, Sarah ; Robart, Emily ; Maldonado, Paulo Nunes ; Khan, Maryiam ; So, Preston ; Levitt, Joe ; Perez, Cynthia ; Visweswaran, Anita ; Roque, Jonasel ; Rivera, Adreanne ; Frankel, Trevor ; Howell, Michelle ; Friedel, Jennifer ; Goff, Jennifer ; Huynh, David ; Tozier, Michael ; Driver, Conner ; Carricato, Michael ; Foster, Alexandra ; Nassar, Paul ; Stout, Lori ; Sibenaller, Zita ; Walter, Alicia ; Mares, Jasmine ; Olson, Logan ; Clinansmith, Bradley ; Gershengorn, Hayley ; McSpadden, EJ ; Truscon, Rachel ; Kaniclides, Anne ; Thomas, Lara ; Bielak, Ramsay ; Valvano, Weronika Damek ; Fong, Rebecca ; Fitzsimmons, William J. ; Blair, Christopher ; Valesano, Andrew L. ; Gilbert, Julie ; Crider, Christine D. ; Steinbock, Kyle A. ; Paulson, Thomas C. ; Anderson, Layla A. ; Kampe, Christy ; Johnson, Jakea ; McHenry, Rendie ; Blair, Marcia ; Conway, Douglas ; LaRose, Mary ; Landreth, Leigha ; Hicks, Madeline ; Parks, Lisa ; Bongu, Jahnavi ; McDonald, David ; Cass, Candice ; Seiler, Sondra ; Park, David ; Hink, Tiffany ; Wallace, Meghan ; Burnham, Carey-Ann ; Arter, Olivia G. ; Tenforde, Mark W. ; Self, Wesley H. ; Naioti, Eric A. ; Ginde, Adit A. ; Douin, David J. ; Olson, Samantha M. ; Talbot, H. Keipp ; Casey, Jonathan D. ; Mohr, Nicholas M. ; Zepeski, Anne ; Gaglani, Manjusha ; McNeal, Tresa ; Ghamande, Shekhar ; Shapiro, Nathan I. ; Gibbs, Kevin W. ; Files, D. Clark ; Hager, David N. ; Shehu, Arber ; Prekker, Matthew E. ; Erickson, Heidi L. ; Gong, Michelle N. ; Mohamed, Amira ; Henning, Daniel J. ; Steingrub, Jay S. ; Peltan, Ithan D. ; Brown, Samuel M. ; Martin, Emily T. ; Monto, Arnold S. ; Khan, Akram ; Hough, Catherine L. ; Busse, Laurence W. ; ten Lohuis, Caitlin C. ; Duggal, Abhijit ; Wilson, Jennifer G. ; Gordon, Alexandra June ; Qadir, Nida ; Chang, Steven Y. ; Mallow, Christopher ; Rivas, Carolina ; Babcock, Hilary M. ; Kwon, Jennie H. ; Exline, Matthew C. ; Halasa, Natasha ; Chappell, James D. ; Lauring, Adam S. ; Grijalva, Carlos G. ; Rice, Todd W. ; Jones, Ian D. ; Stubblefield, William B. ; Baughman, Adrienne ; Womack, Kelsey N. ; Lindsell, Christopher J. ; Hart, Kimberly W. ; Zhu, Yuwei ; Stephenson, Meagan ; Schrag, Stephanie J. ; Kobayashi, Miwako ; Verani, Jennifer R. ; Patel, Manish M. ; Calhoun, Nicole ; Murthy, Kempapura ; Herrick, Judy ; McKillop, Amanda ; Hoffman, Eric ; Zayed, Martha ; Smith, Michael ; Settele, Natalie ; Ettlinger, Jason ; Priest, Elisa ; Thomas, Jennifer ; Arroliga, Alejandro ; Beeram, Madhava ; Kindle, Ryan ; Kozikowski, Lori-Ann ; De Souza, Lesley ; Ouellette, Scott ; Thornton-Thompson, Sherell ; Tyler, Patrick ; Mehkri, Omar ; Ashok, Kiran ; Gole, Susan ; King, Alexander ; Poynter, Bryan ; Stanley, Nicholas ; Hendrickson, Audrey ; Maruggi, Ellen ; Scharber, Tyler ; Jorgensen, Jeffrey ; Bowers, Robert ; King, Jennifer ; Aston, Valerie ; Armbruster, Brent ; Rothman, Richard E. ; Nair, Rahul ; Chen, Jen-Ting (Tina) ; Karow, Sarah ; Robart, Emily ; Maldonado, Paulo Nunes ; Khan, Maryiam ; So, Preston ; Levitt, Joe ; Perez, Cynthia ; Visweswaran, Anita ; Roque, Jonasel ; Rivera, Adreanne ; Frankel, Trevor ; Howell, Michelle ; Friedel, Jennifer ; Goff, Jennifer ; Huynh, David ; Tozier, Michael ; Driver, Conner ; Carricato, Michael ; Foster, Alexandra ; Nassar, Paul ; Stout, Lori ; Sibenaller, Zita ; Walter, Alicia ; Mares, Jasmine ; Olson, Logan ; Clinansmith, Bradley ; Gershengorn, Hayley ; McSpadden, EJ ; Truscon, Rachel ; Kaniclides, Anne ; Thomas, Lara ; Bielak, Ramsay ; Valvano, Weronika Damek ; Fong, Rebecca ; Fitzsimmons, William J. ; Blair, Christopher ; Valesano, Andrew L. ; Gilbert, Julie ; Crider, Christine D. ; Steinbock, Kyle A. ; Paulson, Thomas C. ; Anderson, Layla A. ; Kampe, Christy ; Johnson, Jakea ; McHenry, Rendie ; Blair, Marcia ; Conway, Douglas ; LaRose, Mary ; Landreth, Leigha ; Hicks, Madeline ; Parks, Lisa ; Bongu, Jahnavi ; McDonald, David ; Cass, Candice ; Seiler, Sondra ; Park, David ; Hink, Tiffany ; Wallace, Meghan ; Burnham, Carey-Ann ; Arter, Olivia G.
• Corporate Authors:
  IVY Network Investigators ; IVY Network ; IVY Network Investigators ; IVY Network
• Description:
  Real-world evaluations have demonstrated high effectiveness of vaccines against COVID-19-associated hospitalizations (1-4) measured shortly after vaccination; longer follow-up is needed to assess durability of protection. In an evaluation at 21 hospitals in 18 states, the duration of mRNA vaccine (Pfizer-BioNTech or Moderna) effectiveness (VE) against COVID-19-associated hospitalizations was assessed among adults aged ≥18 years. Among 3,089 hospitalized adults (including 1,194 COVID-19 case-patients and 1,895 non-COVID-19 control-patients), the median age was 59 years, 48.7% were female, and 21.1% had an immunocompromising condition. Overall, 141 (11.8%) case-patients and 988 (52.1%) controls were fully vaccinated (defined as receipt of the second dose of Pfizer-BioNTech or Moderna mRNA COVID-19 vaccines ≥14 days before illness onset), with a median interval of 65 days (range = 14-166 days) after receipt of second dose. VE against COVID-19-associated hospitalization during the full Surveillance period was 86% (95% confidence interval [CI] = 82%-88%) overall and 90% (95% CI = 87%-92%) among adults without immunocompromising conditions. VE against COVID-19- associated hospitalization was 86% (95% CI = 82%-90%) 2-12 weeks and 84% (95% CI = 77%-90%) 13-24 weeks from receipt of the second vaccine dose, with no significant change between these periods (p = 0.854). Whole genome sequencing of 454 case-patient specimens found that 242 (53.3%) belonged to the B.1.1.7 (Alpha) lineage and 74 (16.3%) to the B.1.617.2 (Delta) lineage. Effectiveness of mRNA vaccines against COVID-19-associated hospitalization was sustained over a 24-week period, including among groups at higher risk for severe COVID-19; ongoing monitoring is needed as new SARS-CoV-2 Variantss emerge. To reduce their risk for hospitalization, all eligible persons should be offered COVID-19 vaccination.
• Subjects:
  Adolescent Adult Aged CoronaVirus Infections COVID-19 COVID-19 Vaccines Female Hospitalization Humans Male Middle Aged Time Factors Vaccination Vaccines, Synthetic Young Adult

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• Source:
  MMWR Morbidity Mortal Weekly Rep. 70(34):1156-1162 ; MMWR Morbidity Mortal Weekly Rep. 70(34):1156-1162
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)   ; Weekly Report: Morbidity and Mortality Weekly Report (MMWR)  
• DOI:
  http://dx.doi.org/10.15585/mmwr.mm7034e2
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  34437524
• Pubmed Central ID:
  PMC8389395
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  7 pdf pages
• Volume:
  70
• Issue:
  34
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:23cb0fbc12bda1e87c59f07b3764534c3fe74736784cd8254db2909e4fccdeed5b1402ce2059219a6a0ccb623996fe3365bdeb60ac2377686febbd1b57fc975e
• Download URL:
  https://stacks.cdc.gov/view/cdc/109825/cdc_109825_DS1.pdf
• File Type:
  [PDF - 412.62 KB ]