Trends in Nonfatal and Fatal Overdoses Involving Benzodiazepines — 38 States and the District of Columbia, 2019–2020

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Liu, Stephen ; O’Donnell, Julie ; Gladden, R. Matt ; McGlone, Londell ; Chowdhury, Farnaz
• Description:
  Nonfatal and fatal drug overdoses increased overall from 2019 to 2020 (1).* Illicit benzodiazepines (e.g., etizolam, flualprazolam, and flubromazolam)| were increasingly detected among postmortem and clinical samples in 2020, often with opioids,| and might have contributed to overall increases in drug overdoses. Availability of recent multistate trend data on nonfatal benzodiazepine-involved overdoses and involvement of illicit benzodiazepines in overdoses is limited. This data gap was addressed by analyzing annual and quarterly Trends in suspected benzodiazepine-involved nonfatal overdoses| treated in emergency departments (EDs) (benzodiazepine overdose ED visits) during January 2019-December 2020 (32 states and the District of Columbia [DC]) and benzodiazepine-involved overdose deaths (benzodiazepine deaths), which include both illicit and prescription benzodiazepines, during January 2019-June 2020 (23 states) from CDC's Overdose Data to Action (OD2A) program. From 2019 to 2020, benzodiazepine overdose ED visits per 100,000 ED visits increased (23.7%), both with opioid involvement (34.4%) and without (21.0%). From April-June 2019 to April-June 2020, overall benzodiazepine deaths increased 42.9% (from 1,004 to 1,435), prescription benzodiazepine deaths increased 21.8% (from 921 to 1,122), and illicit benzodiazepine deaths increased 519.6% (from 51 to 316). During January-June 2020, most (92.7%) benzodiazepine deaths also involved opioids, mainly illicitly manufactured fentanyls (IMFs) (66.7%). Improving naloxone availability and enhancing treatment access for persons using benzodiazepines and opioids and calling emergency services for overdoses involving benzodiazepines and opioids, coupled with primary Prevention of drug use and misuse, could reduce morbidity and Mortality.
• Subjects:
  Adolescent Adult Aged Benzodiazepines Drug Overdose Female Humans Male Middle Aged Young Adult
• Source:
  MMWR Morbidity Mortal Weekly Rep. 70(34):1136-1141
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/mmwr.mm7034a2
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  34437522
• Pubmed Central ID:
  PMC8389388
• Document Type:
  Journal Article
• Place as Subject:
  District of Columbia ; United States
• Pages in Document:
  6 pdf pages
• Volume:
  70
• Issue:
  34
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:1060fc6767ab2ca08d2e6bc944bc9ac40f5a7b1e1c8106367bde3a692ac58cb302d377691566f7f0753aa46984000b00517343d47dfadb0280b239bba9802804
• Download URL:
  https://stacks.cdc.gov/view/cdc/109818/cdc_109818_DS1.pdf
• File Type:
  [PDF - 287.86 KB ]