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Differential Effects of Chlorhexidine Skin Cleansing Methods on Residual Chlorhexidine Skin Concentrations and Bacterial Recovery
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April 2018
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Source: Infect Control Hosp Epidemiol. 39(4):405-411
[PDF-381.86 KB]
Details:
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Alternative Title:Infect Control Hosp Epidemiol
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Personal Author:
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Description:BACKGROUND.
Bathing intensive care unit (ICU) patients with 2% chlorhexidine gluconate (CHG)–impregnated cloths decreases the risk of healthcare-associated bacteremia and multidrug-resistant organism transmission. Hospitals employ different methods of CHG bathing, and few studies have evaluated whether those methods yield comparable results.
OBJECTIVE.
To determine whether 3 different CHG skin cleansing methods yield similar residual CHG concentrations and bacterial densities on skin.
DESIGN.
Prospective, randomized 2-center study with blinded assessment.
PARTICIPANTS AND SETTING.
Healthcare personnel in surgical ICUs at 2 tertiary-care teaching hospitals in Chicago, Illinois, and Boston, Massachusetts, from July 2015 to January 2016.
INTERVENTION.
Cleansing skin of one forearm with no-rinse 2% CHG-impregnated polyester cloth (method A) versus 4% CHG liquid cleansing with rinsing on the contralateral arm, applied with either non–antiseptic-impregnated cellulose/polyester cloth (method B) or cotton washcloth dampened with sterile water (method C).
RESULTS.
In total, 63 participants (126 forearms) received method A on 1 forearm (n =63). On the contralateral forearm, 33 participants received method B and 30 participants received method C. Immediately and 6 hours after cleansing, method A yielded the highest residual CHG concentrations (2500 μg/mL and 1250 μg/mL, respectively) and lowest bacterial densities compared to methods B or C (P<.001).
CONCLUSION.
In healthy volunteers, cleansing with 2% CHG-impregnated cloths yielded higher residual CHG concentrations and lower bacterial densities than cleansing with 4% CHG liquid applied with either of 2 different cloth types and followed by rinsing. The relevance of these differences to clinical outcomes remains to be determined.
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Source:
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Pubmed ID:29493475
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Pubmed Central ID:PMC8381229
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Document Type:
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Funding:
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Volume:39
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Issue:4
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