Details:

Alternative Title:
Infect Control Hosp Epidemiol
Personal Author:
Rhee, Yoona ; Palmer, Louisa J. ; Okamoto, Koh ; Gemunden, Sean ; Hammouda, Khaled ; ... More +
Rhee, Yoona ; Palmer, Louisa J. ; Okamoto, Koh ; Gemunden, Sean ; Hammouda, Khaled ; Kemble, Sarah K. ; Lin, Michael Y. ; Lolans, Karen ; Fogg, Louis ; Guanaga, Derek ; Yokoe, Deborah S. ; Weinstein, Robert A. ; Frendl, Gyorgy ; Hayden, Mary K. Less -
Description:
BACKGROUND.

Bathing intensive care unit (ICU) patients with 2% chlorhexidine gluconate (CHG)–impregnated cloths decreases the risk of healthcare-associated bacteremia and multidrug-resistant organism transmission. Hospitals employ different methods of CHG bathing, and few studies have evaluated whether those methods yield comparable results.

OBJECTIVE.

To determine whether 3 different CHG skin cleansing methods yield similar residual CHG concentrations and bacterial densities on skin.

DESIGN.

Prospective, randomized 2-center study with blinded assessment.

PARTICIPANTS AND SETTING.

Healthcare personnel in surgical ICUs at 2 tertiary-care teaching hospitals in Chicago, Illinois, and Boston, Massachusetts, from July 2015 to January 2016.

INTERVENTION.

Cleansing skin of one forearm with no-rinse 2% CHG-impregnated polyester cloth (method A) versus 4% CHG liquid cleansing with rinsing on the contralateral arm, applied with either non–antiseptic-impregnated cellulose/polyester cloth (method B) or cotton washcloth dampened with sterile water (method C).

RESULTS.

In total, 63 participants (126 forearms) received method A on 1 forearm (n =63). On the contralateral forearm, 33 participants received method B and 30 participants received method C. Immediately and 6 hours after cleansing, method A yielded the highest residual CHG concentrations (2500 μg/mL and 1250 μg/mL, respectively) and lowest bacterial densities compared to methods B or C (P<.001).

CONCLUSION.

In healthy volunteers, cleansing with 2% CHG-impregnated cloths yielded higher residual CHG concentrations and lower bacterial densities than cleansing with 4% CHG liquid applied with either of 2 different cloth types and followed by rinsing. The relevance of these differences to clinical outcomes remains to be determined.


Subjects:
[+]
Adult Anti-Infective Agents, Local Article Bacteremia Baths Chlorhexidine Critical Care Cross Infection Disease Transmission, Infectious Female Humans Infection Control Male Skin Skin Care Treatment Outcome
Source:
Infect Control Hosp Epidemiol. 39(4):405-411
Pubmed ID:
29493475
Pubmed Central ID:
PMC8381229
Document Type:
Journal Article
Funding:
U54 CK000481/CK/NCEZID CDC HHSUnited States/
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:c17915a3a04253553793d0f9057c6d04607af0997cea6e679131964632f24b55
Download URL:
https://stacks.cdc.gov/view/cdc/109152/cdc_109152_DS1.pdf
File Type:

Supporting Files

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