Humoral signatures of protective and pathological SARS-CoV-2 infection in children

Details

• Alternative Title:
  Nat Med
• Personal Author:
  Bartsch, Yannic C ; Wang, Chuangqi ; Zohar, Tomer ; Fischinger, Stephanie ; Atyeo, Caroline ; Burke, John ; Kang, Jaewon ; Edlow, Andrea G ; Fasano, Alessio ; Baden, Lindsey R ; Nilles, Eric J ; Woolley, Ann E ; Karlson, Elizabeth Wood ; Hopke, Alex R ; Irimia, Daniel ; Fischer, Eric S ; Ryan, Edward T. ; Charles, Richelle ; Julg, Boris D. ; Lauffenburger, Douglas A ; Yonker, Lael M ; Alter, Galit
• Description:
  The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to spread relentlessly, associated with a high frequency of respiratory failure and mortality. Children experience largely asymptomatic disease, with rare reports of multisystem inflammatory syndrome in children (MIS-C). Identifying immune mechanisms that result in these disparate clinical phenotypes in children could provide critical insights into coronavirus disease 2019 (COVID-19) pathogenesis. Using systems serology, in this study we observed in 25 children with acute mild COVID-19 a functional phagocyte and complement-activating IgG response to SARS-CoV-2, similar to the acute responses generated in adults with mild disease. Conversely, IgA and neutrophil responses were significantly expanded in adults with severe disease. Moreover, weeks after the resolution of SARS-CoV-2 infection, children who develop MIS-C maintained highly inflammatory monocyte-activating SARS-CoV-2 IgG antibodies, distinguishable from acute disease in children but with antibody levels similar to those in convalescent adults. Collectively, these data provide unique insights into the potential mechanisms of IgG and IgA that might underlie differential disease severity as well as unexpected complications in children infected with SARS-CoV-2.
• Subjects:
  Adolescent Adult Aged Age Of Onset Antibodies, Neutralizing Antibodies, Viral Asymptomatic Infections Carrier State Child Child, Preschool Cohort Studies Coronavirus Infections COVID-19 Female Humans Immunity Immunoglobulin A Immunoglobulin G Infant Infant, Newborn Male Middle Aged Pandemics SARS-CoV-2 Severity Of Illness Index Systemic Inflammatory Response Syndrome Young Adult

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• Source:
  Nat Med. 27(3):454-462
• Pubmed ID:
  33589825
• Pubmed Central ID:
  PMC8315827
• Document Type:
  Journal Article
• Funding:
  3R37AI080289-11S1/U.S. Department of Health & Human Services ; National Institutes of Health (NIH)/ ; YONKER18Q0/Cystic Fibrosis Foundation (CF Foundation)/ ; U19 AI142790/AI/NIAID NIH HHSUnited States/ ; R01 AI146779/AI/NIAID NIH HHSUnited States/ ; 5K08HL143183/U.S. Department of Health & Human Services ; NIH ; National Heart, Lung, and Blood Institute (NHLBI)/ ; U01CK0009490/U.S. Department of Health & Human Services ; Centers for Disease Control and Prevention (CDC)/ ; Global Health Vaccine Accelerator Platform/Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation)/ ; U01CK000490/ACL/ACL HHSUnited States/ ; R01 HD100022/HD/NICHD NIH HHSUnited States/ ; U19 AI135995/AI/NIAID NIH HHSUnited States/ ; U01 CA260476/CA/NCI NIH HHSUnited States/ ; R37 AI080289/AI/NIAID NIH HHSUnited States/ ; K08 HL143183/HL/NHLBI NIH HHSUnited States/ ; U01CA260476/U.S. Department of Health & Human Services
• Volume:
  27
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:898ffd9e80b74970361594f853d6636543daf5bcab187d0b9dbbacd929b025f8
• Download URL:
  https://stacks.cdc.gov/view/cdc/108324/cdc_108324_DS1.pdf
• File Type:
  [PDF - 1.94 MB ]