Pediatric Q Fever

Details

• Alternative Title:
  Curr Infect Dis Rep
• Personal Author:
  Cherry, Cara C. ; Kersh, Gilbert J.
• Description:
  Purpose of Review
  
  The non-specific presentation of acute Q fever makes it difficult to diagnose in children, but untreated Q fever can result in chronic infections that have severe complications.
  
  Recent Findings
  
  Pediatric Q fever cases continue to be infrequently reported in the literature, and primarily document cases of persistent infections with Coxiella burnetii. Standardized treatment protocols for chronic Q fever in children still do not exist. Doxycycline and hydroxychloroquine are the treatment combination most utilized by healthcare providers to treat Q fever endocarditis or osteomyelitis in children, but a variety of other antibiotic combinations have been reported with varying results. The use of adjunctive therapies, such as such as interferon gamma, has produced mixed outcomes.
  
  Summary
  
  The true impact of Coxiella burnetii on the health of children remains unknown; long-term longitudinal follow-up of children with acute or chronic Q fever has not been reported. Both the acute and chronic forms of Q fever are underreported and underdiagnosed. Healthcare providers should consider Q fever in pediatric patients with culture-negative endocarditis or osteomyelitis.
  
  
• Subjects:
  Article Children Coxiella Burnetii Pediatric Q Fever
• Source:
  Curr Infect Dis Rep. 22(4)
• Pubmed ID:
  34135692
• Pubmed Central ID:
  PMC8205507
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHS/United States
• Volume:
  22
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:1e961373c3203687e49bbd49f7f2c3996472dcceb8ebcaab2858bcfa6e4a2a9f
• Download URL:
  https://stacks.cdc.gov/view/cdc/107403/cdc_107403_DS1.pdf
• File Type:
  [PDF - 426.42 KB ]