Seroprevalence of SARS-CoV-2 following the largest initial epidemic wave in the United States: Findings from New York City, May 13-July 21, 2020

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Pathela, Preeti ; Crawley, Addie ; Weiss, Don ; Maldin, Beth ; Cornell, Jennifer ; Purdin, Jeff ; Schumacher, Pamela K ; Marovich, Stacey ; Li, Joyce ; Daskalakis, Demetre
• Corporate Authors:
  NYC Serosurvey Team
• Description:
  Background ; New York City (NYC) was the U.S. epicenter of the Spring 2020 COVID-19 pandemic. We present seroprevalence of SARS-CoV-2 infection and correlates of seropositivity immediately after the first wave. ; Methods ; From a serosurvey of adult NYC residents (May 13-July 21, 2020), we calculated the prevalence of SARS-CoV-2 antibodies stratified by participant demographics, symptom history, health status, and employment industry. We used multivariable regression models to assess associations between participant characteristics and seropositivity. ; Results ; Seroprevalence among 45,367 participants was 23.6% (95% CI, 23.2%-24.0%). High seroprevalence (>30%) was observed among Black and Hispanic individuals, people from high poverty neighborhoods, and people in health care or essential worker industry sectors. COVID-19 symptom history was associated with seropositivity (adjusted relative risk=2.76; 95% CI, 2.65-2.88). Other risk factors included sex, age, race/ethnicity, residential area, employment sector, working outside the home, contact with a COVID-19 case, obesity, and increasing numbers of household members. ; Conclusions ; Based on a large serosurvey in a single U.S. jurisdiction, we estimate that just under one-quarter of NYC adults were infected in the first few months of the COVID-19 epidemic. Given disparities in infection risk, effective interventions for at-risk groups are needed during ongoing transmission.
• Subjects:
  • Major Article
  • AcademicSubjects/MED00290
  • SARS-CoV-2
  • seroprevalence
  • seroepidemiology
• Source:
  J Infect Dis. 2021;
• Pubmed ID:
  33836067
• Pubmed Central ID:
  PMC8083309
• Document Type:
  Journal Article
• Download URL:
  https://stacks.cdc.gov/view/cdc/107346/cdc_107346_DS1.pdf
• File Type:
  [PDF - 943.64 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b8e70569269c6186a94cb17acb66aadf8e3acbba843e4da2dc9814c088ba14f4