Symptoms and recovery among adult outpatients with and without COVID‐19 at 11 healthcare facilities—July 2020, United States

Details

• Alternative Title:
  Influenza Other Respir Viruses
• Personal Author:
  Fisher, Kiva A. ; Olson, Samantha M. ; Tenforde, Mark W. ; Self, Wesley H. ; Wu, Michael ; Lindsell, Christopher J. ; Shapiro, Nathan I. ; Files, D. Clark ; Gibbs, Kevin W. ; Erickson, Heidi L. ; Prekker, Matthew E. ; Steingrub, Jay S. ; Exline, Matthew C. ; Henning, Daniel J. ; Wilson, Jennifer G. ; Brown, Samuel M. ; Peltan, Ithan D. ; Rice, Todd W. ; Hager, David N. ; Ginde, Adit A. ; Talbot, H. Keipp ; Casey, Jonathan D. ; Grijalva, Carlos G. ; Flannery, Brendan ; Patel, Manish M. ; Feldstein, Leora R. ; Hart, Kimberly W. ; McClellan, Robert ; Tan, Hsi‐nien ; Baughman, Adrienne ; Hennesy, Nora A. ; Grear, Brittany ; Mlynarczyk, Kristin ; Marzano, Luc ; Plata, Zuwena ; Caplan, Alexis ; Ogokeh, Constance E. ; Smith, Emily R. ; Kim, Sara S. ; Griggs, Eric P. ; Richards, Bridget ; Robinson, Sonya ; Kim, Kaylee ; Kassem, Ahmed M. ; Sciarratta, Courtney N. ; Marcet, Paula L.
• Description:
  Background
  
  Symptoms of mild COVID‐19 illness are non‐specific and may persist for prolonged periods. Effects on quality of life of persistent poor physical or mental health associated with COVID‐19 are not well understood.
  
  Methods
  
  Adults aged ≥18 years with laboratory‐confirmed COVID‐19 and matched control patients who tested negative for SARS‐CoV‐2 infection at outpatient facilities associated with 11 medical centers in the United States were interviewed to assess symptoms, illness duration, and health‐related quality of life. Duration of symptoms, health‐related quality of life measures, and days of poor physical health by symptoms experienced during illness were compared between case patients and controls using Wilcoxon rank‐sum tests. Symptoms associated with COVID‐19 case status were evaluated by multivariable logistic regression.
  
  Results
  
  Among 320 participants included, 157 were COVID‐19 cases and 163 were SARS‐CoV‐2 negative controls. Loss of taste or smell was reported by 63% of cases and 6% of controls and was strongly associated with COVID‐19 in logistic regression models (adjusted odds ratio [aOR] = 32.4; 95% confidence interval [CI], 12.6‐83.1). COVID‐19 cases were more likely than controls to have experienced fever, body aches, weakness, or fatigue during illness, and to report ≥1 persistent symptom more than 14 days after symptom onset (50% vs 32%, P < .001). Cases reported significantly more days of poor physical health during the past 14 days than controls (P < .01).
  
  Conclusions
  
  Differentiating COVID‐19 from other acute illnesses will require widespread diagnostic testing, especially during influenza seasons. Persistent COVID‐19‐related symptoms may negatively affect quality of life, even among those initially presenting with mild illness.
  
  
• Subjects:
  Adult Case-Control Studies Coronavirus Infections COVID-19 Female Health Facilities Humans Logistic Models Male Middle Aged Outpatients Quality Of Life SARS-CoV-2

  More +
• Source:
  Influenza Other Respir Viruses. 15(3):345-351
• Pubmed ID:
  33405338
• Pubmed Central ID:
  PMC8051737
• Document Type:
  Journal Article
• Funding:
  K23 GM129661/GM/NIGMS NIH HHS/United States ; K23 HL153584/HL/NHLBI NIH HHS/United States ; UL1TR000445/NCATS/NIH/ ; 75D30120C07637/CC/CDC HHS/United States
• Place as Subject:
  United States
• Volume:
  15
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:27f49fe35d649003b23e5861405cd5daa78a7ca6e0ce534a002b801a9965c823
• Download URL:
  https://stacks.cdc.gov/view/cdc/107343/cdc_107343_DS1.pdf
• File Type:
  [PDF - 402.87 KB ]