Interim Estimates of Vaccine Effectiveness of Pfizer-BioNTech and Moderna Covid-19 Vaccines Among Health Care Personnel — 33 U.S. Sites, January–March 2021

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Pilishvili, Tamara ; Fleming-Dutra, Katherine E. ; Farrar, Jennifer L. ; Gierke, Ryan ; Mohr, Nicholas M. ; Talan, David A. ; Krishnadasan, Anusha ; Harland, Karisa K. ; Smithline, Howard A. ; Hou, Peter C. ; Lee, Lilly C. ; Lim, Stephen C. ; Moran, Gregory J. ; Krebs, Elizabeth ; Steele, Mark ; Beiser, David G. ; Faine, Brett ; Haran, John P. ; Nandi, Utsav ; Schrading, Walter A. ; Chinnock, Brian ; Henning, Daniel J. ; LoVecchio, Frank ; Nadle, Joelle ; Barter, Devra ; Brackney, Monica ; Britton, Amber ; Marceaux-Galli, Kaytlynn ; Lim, Sarah ; Phipps, Erin C. ; Dumyati, Ghinwa ; Pierce, Rebecca ; Markus, Tiffanie M. ; Anderson, Deverick J. ; Debes, Amanda K. ; Lin, Michael ; Mayer, Jeanmarie ; Babcock, Hilary M. ; Safdar, Nasia ; Fischer, Marc ; Singleton, Rosalyn ; Chea, Nora ; Magill, Shelley S. ; Verani, Jennifer ; Schrag, Stephanie ; Yousaf, Anna ; Chung, Yunmi ; Onukwube, Jennifer ; Xing, Wei ; Clinansmith, Bradley ; Uribe, Lisandra ; Poronsky, Kye E. ; Hashimoto, Dean M. ; Bahamon, Monica ; St. Romain, Michelle ; Kean, Efrat ; Stubbs, Amy ; Roy, Sara ; Volturo, Gregory ; Galbraith, James ; Crosby, James C. ; Fuentes, Megan R. ; Mulrow, Mary ; Lee, Jane ; Johnston, Helen ; Hansen, AmberJean ; Fridkin, Scott K. ; Wilson, Lucy E. ; Lovett, Sara ; Christian, Melissa ; Myers, Christopher ; Ocampo, Valerie L.S. ; Talbot, Keipp ; Seidelman, Jessica ; Milstone, Aaron M. ; Hayden, Mary ; Samore, Matthew ; Kwon, Jennie H. ; Shirley, Daniel ; Dillard, Denise ; Dobson, Jennifer
• Corporate Authors:
  Vaccine Effectiveness Among Healthcare Personnel Study Team
• Description:
  Throughout the COVID-19 pandemic, health care personnel (HCP) have been at high risk for exposure to SARS-CoV-2, the Virus that causes COVID-19, through patient interactions and community exposure (1). The Advisory Committee on Immunization Practices recommended prioritization of HCP for COVID-19 vaccination to maintain provision of critical services and reduce spread of infection in health care settings (2). Early distribution of two mRNA COVID-19 vaccines (Pfizer-BioNTech and Moderna) to HCP allowed assessment of the effectiveness of these vaccines in a real-world setting. A test-negative case-control study is underway to evaluate mRNA COVID-19 vaccine effectiveness (VE) against symptomatic illness among HCP at 33 U.S. sites across 25 U.S. states. Interim analyses indicated that the VE of a single dose (measured 14 days after the first dose through 6 days after the second dose) was 82% (95% confidence interval [CI] = 74%-87%), adjusted for age, race/ethnicity, and underlying medical conditions. The adjusted VE of 2 doses (measured ≥7 days after the second dose) was 94% (95% CI = 87%-97%). VE of partial (1-dose) and complete (2-dose) vaccination in this population is comparable to that reported from clinical trials and recent observational studies, supporting the effectiveness of mRNA COVID-19 vaccines against symptomatic disease in adults, with strong 2-dose protection.
• Subjects:
  Adult Aged Case-Control Studies CoronaVirus Infections COVID-19 COVID-19 Testing COVID-19 Vaccines Female Health Personnel Humans Immunization Schedule Male Middle Aged Occupational Diseases Young Adult

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• Source:
  MMWR Morbidity Mortal Weekly Rep. 70(20):753-758
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  34014909
• Pubmed Central ID:
  PMC8136422
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  6 pdf pages
• Volume:
  70
• Issue:
  20
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:1b7a387f8a98ce60c0bf29a6132930c9040cda6e58795694aab91cf4c57caa19c7cb652bcb39b16f536205cbcb26e1c49eaf6e48e37b584334c74582a1a50efe
• Download URL:
  https://stacks.cdc.gov/view/cdc/106676/cdc_106676_DS1.pdf
• File Type:
  [PDF - 122.43 KB ]