The Advisory Committee on Immunization Practices’ Interim Recommendation for Use of Pfizer-BioNTech COVID-19 Vaccine in Adolescents Aged 12–15 Years — United States, May 2021

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Wallace, Megan ; Woodworth, Kate R. ; Gargano, Julia W. ; Scobie, Heather M. ; Blain, Amy E. ; Moulia, Danielle ; Chamberland, Mary ; Reisman, Nicole ; Hadler, Stephen C. ; MacNeil, Jessica R. ; Campos-Outcalt, Doug ; Morgan, Rebecca L. ; Daley, Matthew F. ; Romero, José R. ; Talbot, H. Keipp ; Lee, Grace M. ; Bell, Beth P. ; Oliver, Sara E.
• Corporate Authors:
  United States. Advisory Committee on Immunization Practices.
• Description:
  The Pfizer-BioNTech COVID-19 (BNT162b2) vaccine is a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine encoding the prefusion spike glycoprotein of SARS-CoV-2, the virus that causes COVID-19. Vaccination with the Pfizer-BioNTech COVID-19 vaccine consists of 2 intramuscular doses (30 μg, 0.3 mL each) administered 3 weeks apart. On December 11, 2020, the Food and Drug Administration (FDA) issued an Emergency Use Authorization (EUA) for use of the Pfizer-BioNTech COVID-19 vaccine (Pfizer, Inc; Philadelphia, Pennsylvania) in persons aged ≥16 years (1); on December 12, 2020, the Advisory Committee on Immunization Practices (ACIP) issued an interim recommendation for use of the vaccine in the same age group (2). As of May 12, 2021, approximately 141.6 million doses of the Pfizer-BioNTech COVID-19 vaccine had been administered to persons aged ≥16 years.* On May 10, 2021, FDA expanded the EUA for the Pfizer-BioNTech COVID-19 vaccine to include adolescents aged 12-15 years (1). On May 12, 2021, ACIP issued an interim recommendation| for use of the Pfizer-BioNTech COVID-19 vaccine in adolescents aged 12-15 years for the prevention of COVID-19. To guide its deliberations regarding the vaccine, ACIP used the Evidence to Recommendation (EtR) Framework,| using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach.| The ACIP recommendation for the use of the Pfizer-BioNTech COVID-19 vaccine in persons aged ≥12 years under an EUA is interim and will be updated as additional information becomes available.
• Subjects:
  Adolescent Advisory Committees Child Coronavirus Infections COVID-19 COVID-19 Vaccines Drug Approval Humans Immunization Practice Guidelines As Topic
• Source:
  MMWR Morbidity Mortal Weekly Rep. 70(20):749-752
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  34014913
• Pubmed Central ID:
  PMC8136423
• Document Type:
  Journal Article
• Genre:
  Guideline
• Place as Subject:
  United States
• Location:
  North America
• Pages in Document:
  4 pdf pages
• Volume:
  70
• Issue:
  20
• Collection(s):
  Advisory Committee on Immunization Practices (ACIP) Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:897e28bc906cf03d95f60348111e218c5ddf9b3d186149a3c4100cdb6317b4d88661782e7757dd9ac8c454d2c54e5b8d26c5f2a7dbc3daade6d78d86bdda21a8
• Download URL:
  https://stacks.cdc.gov/view/cdc/106675/cdc_106675_DS1.pdf
• File Type:
  [PDF - 86.57 KB ]