Details:

Alternative Title:
Clin Lung Cancer
Publisher's site:
http://dx.doi.org/10.1016/j.cllc.2020.11.005
Personal Author:
Li, Tianhong ; Pan, Kevin ; Ellinwood, Amy K. ; Cress, Rosemary D.
Li, Tianhong ; Pan, Kevin ; Ellinwood, Amy K. ; Cress, Rosemary D. Less -
Description:
Background:

We analyzed the survival trends for patients with metastatic lung cancer in California.

Methods:

We identified patients first diagnosed with primary lung cancer at distant (metastatic) stage in the California Cancer Registry (CCR) between 1990 and 2014, with follow-up through end of 2015. Race/ethnicity was categorized into non-Hispanic white (NHW), non-Hispanic black (NHB), Hispanic, and Asian/Pacific Islander (API). One-year and five-year relative survival rates were calculated overall and by age at diagnosis, sex, race/ethnicity, and histology during the study period. Joinpoint regression was used to evaluate the trends and to calculate the annual percentage changes (APCs).

Results:

A total of 186,156 adults were identified for analysis. Between 1990 and 2014, one-year relative survival significantly improved from 18.4% to 29.4%, with most improvement observed between 1993 and 2012 (APC=2.60%, 95% CI: 2.41–2.79, p<0.01). Five-year relative survival significantly improved from 2.2% to 5.0%, with an APC of 4.05% (95% CI: 3.47–4.64, p<0.01). All age groups experienced an improvement in survival rates. The greatest increases in relative survival were observed among females, APIs, and patients with adenocarcinoma. Yearly survival rates increased for all histologic types over the study period, with adenocarcinoma having the most improvement after 2000.

Conclusions:

Survival for patients with metastatic lung cancer in California steadily improved during the 1990–2014 period, before the era of lung cancer screening and cancer immunotherapy. The greatest increase in relative survival was observed in those patients who have the most clinical benefit from the history- and biomarker-based precision oncology drugs during the study period.


Subject:
[+]
Adenocarcinoma Of Lung
Adult
Aged
Age Distribution
Ethnicity
Female
Humans
Lung Neoplasms
Male
Middle Aged
Racial Groups
Registries
Sex Distribution
Survival Rate
Young Adult

Source:
Clin Lung Cancer. 22(4):e602-e611
Pubmed ID:
33414054
Pubmed Central ID:
PMC8141544
Document Type:
Journal Article
Funding:
HHSN261201800009C/CA/NCI NIH HHSUnited States/ ; NU58DP006344/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201800015I/CA/NCI NIH HHSUnited States/ ; HHSN261201800032I/CA/NCI NIH HHSUnited States/ ; HHSN261201800015C/CA/NCI NIH HHSUnited States/ ; ... More +
HHSN261201800009C/CA/NCI NIH HHSUnited States/ ; NU58DP006344/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201800015I/CA/NCI NIH HHSUnited States/ ; HHSN261201800032I/CA/NCI NIH HHSUnited States/ ; HHSN261201800015C/CA/NCI NIH HHSUnited States/ ; HHSN261201800009I/CA/NCI NIH HHSUnited States/ ; HHSN261201800032C/CA/NCI NIH HHSUnited States/ ; P30 CA093373/CA/NCI NIH HHSUnited States/ Less -
Place as Subject:
California
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:cad24f8dd97dde144f8abda1e4fff14419ff940b8fb709b7ee91092c7e1e7fd3
File Type:

Supporting Files

• 	NIHMS1659998-supplement-Supplemental__F1.pptx	pptx
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  	NIHMS1659998-supplement-Supplemental_table_1.docx	docx

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