Interim Estimates of Vaccine Effectiveness of Pfizer-BioNTech and Moderna Covid-19 Vaccines Among Health Care Personnel — 33 U.S. Sites, January–March 2021

Details

• Personal Author:
  Pilishvili, Tamara ; Fleming-Dutra, Katherine E. ; Farrar, Jennifer L. ; Gierke, Ryan ; Mohr, Nicholas M. ; Talan, David A. ; Krishnadasan, Anusha ; Harland, Karisa K. ; Smithline, Howard A. ; Hou, Peter C. ; Lee, Lilly C. ; Lim, Stephen C. ; Moran, Gregory J. ; Krebs, Elizabeth ; Steele, Mark ; Beiser, David G. ; Faine, Brett ; Haran, MD, John P. ; Nandi, Utsav ; Schrading, Walter A. ; Chinnock, Brian ; Henning, Daniel J. ; LoVecchio, Frank ; Nadle, Joelle ; Barter, Devra ; Brackney, Monica ; Britton, Amber ; Marceaux-Galli, Kaytlynn ; Lim, Sarah ; Phipps, Erin C. ; Dumyati, Ghinwa ; Pierce, Rebecca ; Markus, Tiffanie M. ; Anderson, Deverick J. ; Debes, Amanda K. ; Lin, Michael ; Mayer, Jeanmarie ; Babcock, Hilary M. ; Safdar, Nasia ; Fischer, Marc ; Singleton, Rosalyn ; Chea, Nora ; Magill, Shelley S. ; Verani, Jennifer ; Schrag, Stephanie
• Corporate Authors:
  CDC COVID- Response Team ; University of Iowa. ; Olive View–University of California Los Angeles Medical Center, Los Angeles, California ; Baystate Medical Center, Springfield, Massachusetts ; Brigham and Women’s Hospital, Boston, Massachusetts ; Jackson Memorial Hospital. ; Louisiana State University. ; Thomas Jefferson University Hospital. ; Truman Medical Center. ; University of Chicago. ; University of Massachusetts. ; University of Mississippi. ; University of Alabama at Birmingham. ; University of California San Francisco. ; University of Washington. ; Valleywise Health Medical Center (Phoenix, Arizona) ; California Emerging Infections Program. ; Colorado. Department of Public Health and Environment. ; Connecticut Emerging Infections Program. ; Georgia Emerging Infections Program. ; Emory University School of Medicine. ; Maryland. Department of Health. ; Minnesota. Department of Health. Minnesota Emerging Infections Program. ; University of New Mexico. ; New Mexico Emerging Infections Program. ; University of Rochester Medical Center. New York State—Rochester Emerging Infections Program. ; Oregon Health Authority. Public Health Division. ; Vanderbilt University Medical Center. ; Duke University School of Medicine. Duke Center for Antimicrobial Stewardship and Infection Prevention. ; Johns Hopkins School of Public Health. ; Rush University Medical Center. Department of Medicine. ; University of Utah/VA Salt Lake City Health Care System. ; Washington University (St. Louis, Mo.). School of Medicine. ; University of Wisconsin—Madison. ; William S. Middleton Memorial Veterans Hospital (Madison, Wisconsin) ; Alaska Native Tribal Health Consortium.
• Description:
  What is already known about this topic? Health care personnel (HCP) are at high risk for COVID-19. The early distribution of two mRNA COVID-19 vaccines (Pfizer-BioNTech and Moderna) to HCP provided an opportunity to examine vaccine effectiveness in a real-world setting.
  
  What is added by this report? The first U.S. multisite test-negative design vaccine effectiveness study among HCP found a single dose of Pfizer-BioNTech or Moderna Covid-19 Vaccines to be 82% effective against symptomatic COVID-19 and 2 doses to be 94% effective.
  
  What are the implications for public health practice? The mRNA vaccines are highly effective at preventing symptomatic COVID-19 among U.S. HCP. High vaccination coverage among HCP and the general population is critical to prevent COVID-19 in the United Statesmm7020e2.htm?s_cid=mm7020e2_w
  
  mm7020e2-H.pdf
  
  
• Subjects:
  CoronaVirus Infections/Prevention & Control COVID-19 Vaccines COVID-19/Prevention & Control Health Personnel Vaccines, Synthetic
• Source:
  MMWR: Morbidity and Mortality Weekly Report 2021; v. 70 Early Release
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Document Type:
  Journal Article
• Name as Subject:
  Moderna Covid-19 Vaccine ; Pfizer-BioNTech COVID-19 Vaccine
• Place as Subject:
  United States
• Pages in Document:
  6 pdf pages
• Volume:
  70
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:5edf109f87546f7824f882b4fdeb87bf8bd3103c2aca8c792ab886f28d4a487abe789b9bd849e49894cbd983107da6758fcaf0cb13772e7d753e4a76a6e39fff
• Download URL:
  https://stacks.cdc.gov/view/cdc/106200/cdc_106200_DS1.pdf
• File Type:
  [PDF - 144.72 KB ]