COVID-19 Outbreak Associated with a SARS-CoV-2 R.1 Lineage Variant in a Skilled Nursing Facility After Vaccination Program — Kentucky, March 2021

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Cavanaugh, Alyson M. ; Fortier, Sarah ; Lewis, Patricia ; Arora, Vaneet ; Johnson, Matt ; George, Karim ; Tobias, Joshua ; Lunn, Stephanie ; Miller, Taylor ; Thoroughman, Douglas ; Spicer, Kevin B.
• Description:
  Although COVID-19 mRNA vaccines demonstrated high efficacy in clinical trials (1), they were not 100% efficacious. Thus, some infections postvaccination are expected. Limited data are available on effectiveness in skilled nursing facilities (SNFs) and against emerging Variantss. The Kentucky Department for Public Health (KDPH) and a local health department investigated a COVID-19 outbreak in a SNF that occurred after all residents and health care personnel (HCP) had been offered vaccination. Among 83 residents and 116 HCP, 75 (90.4%) and 61 (52.6%), respectively, received 2 vaccine doses. Twenty-six residents and 20 HCP received positive test results for SARS-CoV-2, the Virus that causes COVID-19, including 18 residents and four HCP who had received their second vaccine dose >14 days before the outbreak began. An R.1 lineage Variants was detected with whole genome sequencing (WGS). Although the R.1 Variants has multiple spike protein mutations, vaccinated residents and HCP were 87% less likely to have symptomatic COVID-19 compared with those who were unvaccinated. Vaccination of SNF populations, including HCP, is critical to reduce the risk for SARS-CoV-2 introduction, Transmission, and severe outcomes in SNFs. An ongoing focus on infection Prevention and control practices is also essential.
• Subjects:
  Aged CoronaVirus Infections COVID-19 COVID-19 Vaccines Disease Outbreaks Humans Immunization Programs SARS-CoV-2 Skilled Nursing Facilities
• Source:
  MMWR Morbidity Mortal Weekly Rep. 70(17):639-643
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  33914720
• Pubmed Central ID:
  PMC8084128
• Document Type:
  Journal Article
• Place as Subject:
  Kentucky
• Pages in Document:
  5 pdf pages
• Volume:
  70
• Issue:
  17
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:813961e6209123eae5d58104388949bbf1662e5441df82cfea3c3a49be45a3c0210bb3a2c3ae178289fcc3a1709f62857e322c8218d74f97f4bb44b997e7addf
• Download URL:
  https://stacks.cdc.gov/view/cdc/106183/cdc_106183_DS1.pdf
• File Type:
  [PDF - 120.77 KB ]