COVID-19 breakthrough case investigations and reporting
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COVID-19 breakthrough case investigations and reporting

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  • Corporate Authors:
  • Description:
    This page provides information and resources to help public health departments and laboratories investigate and report COVID-19 vaccine breakthrough cases.

    • Vaccine breakthrough cases are expected. COVID-19 vaccines are effective and are a critical tool to bring the pandemic under control. However no vaccines are 100% effective at preventing illness. There will be a small percentage of people who are fully vaccinated who still get sick, are hospitalized, or die from COVID-19.

    • More than 75 million people in the United States had been fully vaccinated as of April 14, 2021. Like with other vaccines, symptomatic vaccine breakthrough cases will occur, even though the vaccines are working as expected. Asymptomatic infections among vaccinated people also will occur.

    • There is some evidence that vaccination may make illness less severe.

    • Current data suggest that COVID-19 vaccines authorized for use in the United States offer protection against most SARS-CoV-2 variants circulating in the United States. However, variants will cause some of these vaccine breakthrough cases.

  • Content Notes:
    What CDC is doing -- Establishing a vaccine breakthrough case definition -- Identifying and investigating COVID-19 vaccine breakthrough cases -- Developing a data access and management system for COVID-19 vaccine breakthrough cases -- COVID-19 vaccine breakthrough infections reported to CDC -- How to interpret these data -- COVID-19 Vaccines are Effective.
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