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Occupational use of high-level disinfectants and asthma incidence in early to mid-career female nurses: a prospective cohort study
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4 2021
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Source: Occup Environ Med. 78(4):244-247
Details:
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Alternative Title:Occup Environ Med
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Personal Author:
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Description:Objectives:
Occupational use of disinfectants among healthcare workers has been associated with asthma. However, most studies are cross-sectional and longitudinal studies are not entirely consistent. To limit the healthy worker effect, it is important to conduct studies among early to mid-career workers. We investigated the prospective association between use of disinfectants and asthma incidence in a large cohort of early to mid-career female nurses.
Methods:
The Nurses’ Health Study 3 is an ongoing, prospective, internet-based cohort of female nurses in the United States and Canada (2010-present). Analyses included 17,280 participants without history of asthma at study entry (mean age: 34 years) and who had completed ≥1 follow-up questionnaire (sent every 6 months). Occupational use of high-level disinfectants (HLDs) was evaluated by questionnaire. We examined the association between HLD use and asthma development, adjusted for age, race, ethnicity, smoking status, and body mass index.
Results:
During 67,392 person-years of follow-up, 391 nurses reported incident clinician-diagnosed asthma. Compared to nurses who reported ≤5 years of HLD use (89%), those with >5 years of HLD use (11%) had increased risk of incident asthma (adjusted hazard ratio [95%CI], 1.38 [1.03-1.85]). The risk of incident asthma was elevated but not statistically significant in those reporting >5 years of HLD use and current use of ≥2 products (1.72 [0.88-3.34]); asthma risk was significantly elevated in women with >5 years of HLD use but no current use (1.46 [1.00-2.12]).
Conclusions:
Occupational use of high-level disinfectants was prospectively associated with increased asthma incidence in early to mid-career nurses.
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Pubmed ID:33452037
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Pubmed Central ID:PMC7985390
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Volume:78
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Issue:4
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