The path to the standardization of PTH: Is this a realistic possibility? a position paper of the IFCC C-BM

Details

• Alternative Title:
  Clin Chim Acta
• Personal Author:
  Cavalier, Etienne ; Vasikaran, Samuel ; Bhattoa, Harjit P. ; Heijboer, Annemieke C. ; Makris, Konstantinos ; Ulmer, Candice Z.
• Description:
  Parathyroid hormone (PTH) determination is of greatest importance for patients suffering from parathyroid gland disorders and for the follow-up of bone turnover in patients suffering from chronic kidney disease (CKD). Two generations of PTH assays are simultaneously present on the market for PTH quantification. As these assays are not yet standardized, this results in a significant level of confusion in the care of CKD patients. One key objective of the IFCC Committee for Bone Metabolism is to improve this situation. In this position paper, we will highlight the current state of PTH testing and propose a pathway to ultimately overcome issues resulting from PTH assay variability.
• Subjects:
  Humans Immunoassay Kidney Failure, Chronic Parathyroid Hormone Reference Standards Renal Insufficiency, Chronic
• Keywords:
  Immunoassays Parathyroid Hormone Standardization
• Source:
  Clin Chim Acta. 515:44-51
• Pubmed ID:
  33412144
• Pubmed Central ID:
  PMC7920929
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  515
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:51964b1c249f376ae2e367e64783d1190ea3fa015c94b41273996ae4c91f8c8e0e4d5ac98c91c552e4ea6eab1b4302da7345caf5e3e492da661c6d4b9c12b003
• Download URL:
  https://stacks.cdc.gov/view/cdc/103808/cdc_103808_DS1.pdf
• File Type:
  [PDF - 429.81 KB ]