INCIDENCE AND PROGRESSION OF ANKLE OSTEOARTHRITIS: THE JOHNSTON COUNTY OSTEOARTHRITIS PROJECT

Details

• Alternative Title:
  Semin Arthritis Rheum
• Personal Author:
  Jaleel, Ayesha ; Golightly, Yvonne M. ; Alvarez, Carolina ; Renner, Jordan B. ; Nelson, Amanda E.
• Description:
  Objective: ; To determine the incidence and progression of ankle osteoarthritis (OA) and associated risk factors in a community-based cohort of African Americans and whites. Methods: Data were from 541 participants who had standardized lateral and mortise radiography of the ankles in weight bearing at baseline (2013–2015) and follow-up (2017–2018). Incident radiographic ankle OA (rAOA) was defined as a Kellgren-Lawrence grade (KLG) ≥1 at follow-up among ankles with baseline KLG<1; progressive rAOA was a ≥1 KLG increase at follow-up among ankles with KLG≥1 at baseline. Symptoms were assessed using self-reported pain, aching, and stiffness (PAS) on most days and the Foot and Ankle Outcome Score (FAOS) symptoms subscale. Ankle-level logistic regression models were used to assess associations of ankle outcomes with covariates (age, sex, race, body mass index BMI, smoking, number of symptomatic joints, comorbidities, prior ankle injury, and knee or foot OA). ; Results: ; Among ankles without rAOA at baseline, 28% developed incident rAOA, 37% had worsening FAOS symptoms, and 7% had worsening PAS. Incident rAOA and worsening ankle symptoms were associated with higher BMI and symptoms in other joints. Among ankles with baseline rAOA, 4% had progressive rAOA, 35% had worsening of FAOS symptoms, and 9% had worsening PAS. rAOA progression was associated with ankle injury and concomitant knee or foot OA; worsening of symptoms was associated with higher BMI and other symptomatic joints. ; Conclusions: ; Not all ankle OA is post-traumatic. Smoking prevention/cessation, a healthy weight, and injury prevention may be methods for reducing the incidence and progression of rAOA.
• Subjects:
  • Article
  • Ankle
  • osteoarthritis
  • epidemiology
  • radiography
  • symptoms
  • Ankle Joint
  • Disease Progression
  • Humans
  • Incidence
  More +
• Source:
  Semin Arthritis Rheum. 51(1):230-235
• Pubmed ID:
  33385863
• Pubmed Central ID:
  PMC7902450
• Document Type:
  Journal Article
• Funding:
  P60 AR049465/AR/NIAMS NIH HHSUnited States/ ; U01 DP006266/DP/NCCDPHP CDC HHSUnited States/ ; P60 AR030701/AR/NIAMS NIH HHSUnited States/ ; P60 AR064166/AR/NIAMS NIH HHSUnited States/ ; U01 DP003206/DP/NCCDPHP CDC HHSUnited States/ ; P30 AR072580/AR/NIAMS NIH HHSUnited States/
• Volume:
  51
• Issue:
  1
• Download URL:
  https://stacks.cdc.gov/view/cdc/103800/cdc_103800_DS1.pdf
• File Type:
  [PDF - 215.96 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4c6e0ed9da352f1d7f7ba1e6c209e2e8a74614b32715aca213cfdf4204e3bf27