Adherence to oral glucose tolerance testing in children in stage 1 of type 1 diabetes: The TEDDY study

Details

• Alternative Title:
  Pediatr Diabetes
• Personal Author:
  Driscoll, Kimberly A. ; Tamura, Roy ; Johnson, Suzanne Bennett ; Gesualdo, Patricia ; Clasen, Joanna ; Smith, Laura ; Jacobsen, Laura ; Larsson, Helena Elding ; Haller, Michael J.
• Corporate Authors:
  TEDDY Study Group
• Description:
  Objective:
  
  To examine adherence to the oral glucose tolerance test (OGTT) in multiple islet autoantibody children in stage 1 of developing type 1 diabetes (T1D).
  
  Methods:
  
  Children are followed from birth in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Completion of an OGTT is recommended every 6 months in children ≥3 years of age who are multiple islet autoantibody positive. Factors associated with adherence to the OGTT protocol were examined.
  
  Results:
  
  The average subject level adherence with the OGTT protocol was 62% although there were large differences across countries; Finnish participants and older children from Sweden were more adherent than participants from the United States and Germany. Factors associated with nonadherence included having a first-degree relative with T1D, using a local laboratory rather than a TEDDY center for the OGTT, and maternal underestimation of the child’s risk for T1D. Children were more adherent to the OGTT if their mothers: were more satisfied with TEDDY participation, reported monitoring the child for T1D by checking blood glucose levels at home, and viewed participating in TEDDY as the primary way they were monitoring the child for T1D.
  
  Conclusions:
  
  In a study of children in stage 1 of T1D, adherence to an OGTT protocol was suboptimal despite extensive efforts to communicate the child’s high risk to parents. These findings provide important guidance for development of strategies to improve methods for detecting progression or the development of T1D in high-risk pediatric populations.
  
  
• Subjects:
  Article Autoantibodies Child Diabetes Mellitus, Type 1 Female Finland Genetic Risk Genetic Studies Germany Glucose Tolerance Test Humans Islets Of Langerhans Male Patient Compliance Stage 1 Type 1 Diabetes Sweden United States

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• Source:
  Pediatr Diabetes. 22(2):360-368
• Pubmed ID:
  33179853
• Pubmed Central ID:
  PMC7913602
• Document Type:
  Journal Article
• Funding:
  U01 DK063821/DK/NIDDK NIH HHSUnited States/ ; UC4 DK063863/DK/NIDDK NIH HHSUnited States/ ; Juvenile Diabetes Research Foundation (JDRF)/ ; AI/NIAID NIH HHSUnited States/ ; UL1 TR002535/TR/NCATS NIH HHSUnited States/ ; P30 DK116073/DK/NIDDK NIH HHSUnited States/ ; U01 DK063790/DK/NIDDK NIH HHSUnited States/ ; HD/NICHD NIH HHSUnited States/ ; CC/CDC HHSUnited States/ ; UL1 TR000064/TR/NCATS NIH HHSUnited States/ ; HHSN267200700014C/LM/NLM NIH HHSUnited States/ ; U01 DK063836/DK/NIDDK NIH HHSUnited States/ ; U01 DK063829/DK/NIDDK NIH HHSUnited States/ ; U01 DK063865/DK/NIDDK NIH HHSUnited States/ ; UC4 DK095300/DK/NIDDK NIH HHSUnited States/ ; UC4 DK063861/DK/NIDDK NIH HHSUnited States/ ; UC4 DK063829/DK/NIDDK NIH HHSUnited States/ ; ES/NIEHS NIH HHSUnited States/ ; UC4 DK063821/DK/NIDDK NIH HHSUnited States/ ; UC4 DK117483/DK/NIDDK NIH HHSUnited States/ ; UC4 DK063836/DK/NIDDK NIH HHSUnited States/ ; UC4 DK112243/DK/NIDDK NIH HHSUnited States/ ; U01 DK124166/DK/NIDDK NIH HHSUnited States/ ; U01 DK063861/DK/NIDDK NIH HHSUnited States/ ; UC4 DK063865/DK/NIDDK NIH HHSUnited States/ ; U01 DK063863/DK/NIDDK NIH HHSUnited States/ ; UC4 DK106955/DK/NIDDK NIH HHSUnited States/ ; UC4 DK100238/DK/NIDDK NIH HHSUnited States/
• Volume:
  22
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:cf7c315c4a6931b18d96981d7162f696508b97d6382eadb79cb9bfcf4ca68cfd
• Download URL:
  https://stacks.cdc.gov/view/cdc/103640/cdc_103640_DS1.pdf
• File Type:
  [PDF - 336.85 KB ]