Role of Burkholderia pseudomallei–Specific IgG2 in Adults with Acute Melioidosis, Thailand

Chaichana, Panjaporn; Jenjaroen, Kemajittra; Chumseng, Suchintana; Sumonwiriya, Manutsanun; Rongkard, Patpong; Kronsteiner, Barbara; Teparrukkul, Prapit; Limmathurotsakul, Direk; Day, Nicholas P.J.; Chantratita, Narisara; Dunachie, Susanna J

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Role of Burkholderia pseudomallei–Specific IgG2 in Adults with Acute Melioidosis, Thailand

Feb 2021
By Chaichana, Panjaporn ; Jenjaroen, Kemajittra ; Chumseng, Suchintana ; ...
Source: Emerg Infect Dis. 27(2):463-470

[PDF-922.54 KB]

English

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Alternative Title:

Emerg Infect Dis
Personal Author:

Chaichana, Panjaporn ; Jenjaroen, Kemajittra ; Chumseng, Suchintana ; Sumonwiriya, Manutsanun ; Rongkard, Patpong ; ... More +

Chaichana, Panjaporn ; Jenjaroen, Kemajittra ; Chumseng, Suchintana ; Sumonwiriya, Manutsanun ; Rongkard, Patpong ; Kronsteiner, Barbara ; Teparrukkul, Prapit ; Limmathurotsakul, Direk ; Day, Nicholas P.J. ; Chantratita, Narisara ; Dunachie, Susanna J Less -
Description:

Melioidosis is a life-threatening infectious disease caused by the gram-negative bacillus Burkholderia pseudomallei. An effective vaccine is needed, but data on protective immune responses in human melioidosis are lacking. We used ELISA and an antibody-dependent cellular phagocytosis assay to identify the major features of protective antibodies in patients with acute melioidosis in Thailand. We found that high levels of B. pseudomallei-specific IgG2 are associated with protection against death in a multivariable logistic regression analysis adjusting for age, diabetes, renal disease, and neutrophil count. Serum from melioidosis survivors enhanced bacteria uptake into human monocytes expressing FcγRIIa-H/R131, an intermediate-affinity IgG2-receptor, compared with serum from nonsurvivors. We did not find this enhancement when using monocytes carrying the low IgG2-affinity FcγRIIa-R131 allele. The findings indicate the importance of IgG2 in protection against death in human melioidosis, a crucial finding for antibody-based therapeutics and vaccine development.
Subjects:

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Adult Antibodies, Bacterial Burkholderia Pseudomallei Enzyme-Linked Immunosorbent Assay Humans Immunoglobulin G Melioidosis
Source:

Emerg Infect Dis. 27(2):463-470
Pubmed ID:

33496230
Pubmed Central ID:

PMC7853568
Document Type:

Journal Article
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

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urn:sha256:f41285777529eda2faa2f77e12ee79334a84849ce0f31c3ade37f5b4e5cacc3d
Download URL:

https://stacks.cdc.gov/view/cdc/102442/cdc_102442_DS1.pdf
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